ArticleGene expression patterns : GEP2003
Expression of Zfhep/deltaEF1 protein in palate, neural progenitors, and differentiated neurons.
Article in Gene expression patterns : GEP, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration.Cytokine & growth factor reviews · 2025Review
- MicroRNA 302b-3p/302c-3p/302d-3p inhibits epithelial-mesenchymal transition and promotes apoptosis in human endometrial carcinoma cells.OncoTargets and therapy · 2018Article
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- The zinc finger E-box-binding homeobox 1 (The Journal of biological chemistry · 2017Article
- Heterozygous deletions at the ZEB1 locus verify haploinsufficiency as the mechanism of disease for posterior polymorphous corneal dystrophy type 3.European journal of human genetics : EJHG · 2016Article
- Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition.eLife · 2016Article
- ZEB1 Promotes Invasion in Human Fetal Neural Stem Cells and Hypoxic Glioma Neurospheres.Brain pathology (Zurich, Switzerland) · 2015Article
- EGFR inhibition promotes an aggressive invasion pattern mediated by mesenchymal-like tumor cells within squamous cell carcinomas.Molecular cancer therapeutics · 2013Article
- Article
- Down-regulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progression.Neoplasia (New York, N.Y.) · 2013Article
- BMP4 signaling mediates Zeb family in developing mouse tooth.Histochemistry and cell biology · 2012Article
- miR-200b regulates cell migration via Zeb family during mouse palate development.Histochemistry and cell biology · 2012Article
- δEF1 down-regulates ER-α expression and confers tamoxifen resistance in breast cancer.PloS one · 2012Article
- A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors.Cancer research · 2011Article
- Metastatic progression of prostate cancer and e-cadherin regulation by zeb1 and SRC family kinases.The American journal of pathology · 2011Article
- CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer.Journal of cell science · 2011Article
- miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- ZEB1 in Pancreatic Cancer.Cancers · 2010Article
- The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs.Nature cell biology · 2009Article
- Zeb1 represses Mitf and regulates pigment synthesis, cell proliferation, and epithelial morphology.Investigative ophthalmology & visual science · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Zfhep/deltaEF1 is essential for embryonic development. We have investigated the expression pattern of Zfhep protein during mouse embryogenesis. We show expression of Zfhep in the mesenchyme of the palatal shelves, establishing concordance of expression with the reported cleft palate of the deltaEF1-null mice. Zfhep protein is strongly expressed in proliferating progenitors of the nervous system. In most regions of the brain, post-mitotic cells stop expressing Zfhep when they migrate out of the ventricular zone (VZ) and differentiate. However, in the hindbrain, Zfhep protein is also highly expressed in post-mitotic migratory neuronal cells of the precerebellar extramural stream that arise from the neuroepithelium adjacent to the lower rhombic lip. Also, Zfhep is expressed as cells migrate from a narrow region of the pons VZ towards the trigeminal nucleus. Co-expression with Islet1 shows that Zfhep is expressed in motor neurons of the trigeminal nucleus of the pons, but not in the inferior olive motor neurons at E12.5. Therefore, Zfhep is strongly expressed in a tightly regulated pattern in proliferating neural stem cells and a subset of neurons. Zfhep protein is also strongly expressed in trigeminal ganglia, and is moderately expressed in other cranial ganglia. In vitro studies have implicated Zfhep as a repressor of myogenesis, however, we find that Zfhep protein expression increases during muscle differentiation.
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