ArticleThe EMBO journal1992
A new subclass of nucleoporins that functionally interact with nuclear pore protein NSP1.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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Who cites it
99 citing papers in PubMed, 173 citations in OpenAlex.
- Crosstalk between protein kinases Pho85-Pho80 and Rim11 regulates Pah1 phosphatidate phosphatase function in lipid synthesis.The Journal of biological chemistry · 2026Article
- Identification of divergentbioRxiv : the preprint server for biology · 2025Article
- Nuclear warfare: pathogen manipulation of the nuclear pore complex and nuclear functions.mBio · 2025Review
- The Saccharomyces cerevisiae Spo7 basic tail is required for Nem1-Spo7/Pah1 phosphatase cascade function in lipid synthesis.The Journal of biological chemistry · 2024Article
- A simple thermodynamic description of phase separation of Nup98 FG domains.Nature communications · 2022Article
- A conserved tryptophan within the WRDPLVDID domain of yeast Pah1 phosphatidate phosphatase is required for itsThe Journal of biological chemistry · 2017Article
- YeastThe Journal of biological chemistry · 2017Article
- The nuclear pore complex: understanding its function through structural insight.Nature reviews. Molecular cell biology · 2017Review
- Phosphorylation of Dgk1 Diacylglycerol Kinase by Casein Kinase II Regulates Phosphatidic Acid Production in Saccharomyces cerevisiae.The Journal of biological chemistry · 2016Article
- High resolution microscopy reveals the nuclear shape of budding yeast during cell cycle and in various biological states.Journal of cell science · 2016Article
- Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3.The Journal of biological chemistry · 2016Article
- Lipid partitioning at the nuclear envelope controls membrane biogenesis.Molecular biology of the cell · 2015Article
- Architecture of the fungal nuclear pore inner ring complex.Science (New York, N.Y.) · 2015Article
- Yeast Nem1-Spo7 protein phosphatase activity on Pah1 phosphatidate phosphatase is specific for the Pho85-Pho80 protein kinase phosphorylation sites.The Journal of biological chemistry · 2014Article
- Assemblages: functional units formed by cellular phase separation.The Journal of cell biology · 2014Review
- Yeast Pah1p phosphatidate phosphatase is regulated by proteasome-mediated degradation.The Journal of biological chemistry · 2014Article
- PAH1-encoded phosphatidate phosphatase plays a role in the growth phase- and inositol-mediated regulation of lipid synthesis in Saccharomyces cerevisiae.The Journal of biological chemistry · 2013Article
- Transcription factor Reb1p regulates DGK1-encoded diacylglycerol kinase and lipid metabolism in Saccharomyces cerevisiae.The Journal of biological chemistry · 2013Article
- Regulation of lipid droplet and membrane biogenesis by the acidic tail of the phosphatidate phosphatase Pah1p.Molecular biology of the cell · 2013Article
- Monoclonal antibodies recognize gly-leu-phe-gly repeat of nucleoporin nup98 of tetrahymena, yeasts, and humans.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2013Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NSP1 is a nuclear pore protein (nucleoporin) essential for cell growth. To identify the components that functionally interact with NSP1 in the living cell, we developed a genetic screen for mutants that are lethal in a genetic background of mutated, but not wild type NSP1. Fourteen synthetic lethal mutants were obtained, belonging to at least four different complementation groups. The genes of two complementation groups, NSP116 and NSP49, were cloned. Like the previously described nucleoporins, these genes encode proteins with many repeat sequences. NSP116 and NSP49, however, contain a new repetitive sequence motif 'GLFG', which classifies them as a subclass of nucleoporins. NSP116 and NSP49, tagged with the IgG binding domain of protein A and expressed in yeast, are located at the nuclear envelope. These data provide in vivo evidence that distinct subclasses of nucleoporins physically interact or share overlapping function in nuclear pore complexes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.