ArticleThe EMBO journal1992
Chloroplast group III twintron excision utilizing multiple 5'- and 3'-splice sites.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A functional twintron, 'zombie' twintrons and a hypermobile group II intron invading itself in plant mitochondria.Nucleic acids research · 2020Article
- Chloroplast genome expansion by intron multiplication in the basal psychrophilic euglenoidPeerJ · 2017Article
- Analysis of the Mitochondrial Genome in Hypomyces aurantius Reveals a Novel Twintron Complex in Fungi.International journal of molecular sciences · 2016Article
- Article
- Alternative splicing of a group II intron in a surface layer protein gene in Clostridium tetani.Nucleic acids research · 2014Article
- The half-life of the HSV-1 1.5-kb LAT intron is similar to the half-life of the 2.0-kb LAT intron.Journal of neurovirology · 2013Article
- Principles of 3' splice site selection and alternative splicing for an unusual group II intron from Bacillus anthracis.RNA (New York, N.Y.) · 2004Article
- Evidence for the late origin of introns in chloroplast genes from an evolutionary analysis of the genus Euglena.Nucleic acids research · 1995Article
- A nuclear gene of eubacterial origin in Euglena gracilis reflects cryptic endosymbioses during protist evolution.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Chloroplast ribosomes and protein synthesis.Microbiological reviews · 1994Review
- A group III twintron encoding a maturase-like gene excises through lariat intermediates.Nucleic acids research · 1994Article
- Evolutionary relationships among group II intron-encoded proteins and identification of a conserved domain that may be related to maturase function.Nucleic acids research · 1993Article
- Complete sequence of Euglena gracilis chloroplast DNA.Nucleic acids research · 1993Article
- A complex twintron is excised as four individual introns.Nucleic acids research · 1993Article
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Authors and funding
3 authors.
Funding
Abstract
The chloroplast genes of Euglena gracilis contain more than 60 group II and 47 group III introns. Some Euglena chloroplast genes also contain twintrons, introns-within-introns. Two types of twintrons have previously been described, a group II twintron and a mixed group II/group III twintron. We report that four introns, three within the RNA polymerase subunit gene rpoC1 and one within ribosomal protein gene rpl16, with mean lengths twice typical group III introns, are a new type of twintron. The group III twintrons are composed of group III introns within other group III introns. The splicing of the twintrons was analyzed by PCR amplification, cloning and sequencing of cDNAs, and Northern hybridization. Excision of each group III twintron occurs by a two-step, sequential splicing pathway. Removal of the internal introns precedes excision of the external introns. Splicing of internal introns in three of the four group III twintrons involves multiple 5'- and/or 3'-splice sites. With two of the twintrons the proximal 5'-splice site can be spliced to an internal 3'-splice site, yielding alternative 'pseudo' fully spliced mRNAs. Excised group III introns of the rpl16 twintron are not linear RNA molecules but either lariat or circular RNAs, probably a lariat. The origins of alternative splicing and a possible evolutionary relationship between group II, group III and nuclear pre-mRNA introns are discussed.
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