ArticleBMC genomics2003
Identification and phylogenetic analysis of Dictyostelium discoideum kinesin proteins.
Article in BMC genomics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- KIF9 Ameliorates Neuropathology and Cognitive Dysfunction by Promoting Macroautophagy in a Mouse Model of Alzheimer's Disease.Aging cell · 2025Article
- Elucidating the interactions between Kinesin-5/BimC and the microtubule: insights from TIRF microscopy and molecular dynamics simulations.Briefings in bioinformatics · 2025Article
- Bioenergetics of theBiomolecules · 2020Article
- Review
- Force balances between interphase centrosomes as revealed by laser ablation.Molecular biology of the cell · 2019Article
- Adenylyl cyclase A mRNA localized at the back of cells is actively translated in live chemotaxingJournal of cell science · 2018Article
- The crystal structure and biochemical characterization of Kif15: a bifunctional molecular motor involved in bipolar spindle formation and neuronal development.Acta crystallographica. Section D, Biological crystallography · 2014Article
- A kinesin-mediated mechanism that couples centrosomes to nuclei.Cellular and molecular life sciences : CMLS · 2013Article
- In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A retinoblastoma orthologue is a major regulator of S-phase, mitotic, and developmental gene expression in Dictyostelium.PloS one · 2012Article
- Mechanisms and functions of Hedgehog signalling across the metazoa.Nature reviews. Genetics · 2011Review
- Microtubule-nucleus interactions in Dictyostelium discoideum mediated by central motor kinesins.Eukaryotic cell · 2009Article
- Disruption of four kinesin genes in dictyostelium.BMC cell biology · 2008Article
- The localization of inner centromeric protein (INCENP) at the cleavage furrow is dependent on Kif12 and involves interactions of the N terminus of INCENP with the actin cytoskeleton.Molecular biology of the cell · 2007Article
- A "holistic" kinesin phylogeny reveals new kinesin families and predicts protein functions.Molecular biology of the cell · 2006Article
- Comprehensive comparative analysis of kinesins in photosynthetic eukaryotes.BMC genomics · 2006Article
- The complex interplay between the neck and hinge domains in kinesin-1 dimerization and motor activity.Molecular biology of the cell · 2005Article
- The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles.Genome biology · 2005Article
- A mitotic kinesin-like protein required for normal karyokinesis, myosin localization to the furrow, and cytokinesis in Dictyostelium.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKinesins constitute a large superfamily of motor proteins in eukaryotic cells. They perform diverse tasks such as vesicle and organelle transport and chromosomal segregation in a microtubule- and ATP-dependent manner. In recent years, the genomes of a number of eukaryotic organisms have been completely sequenced. Subsequent studies revealed and classified the full set of members of the kinesin superfamily expressed by these organisms. For Dictyostelium discoideum, only five kinesin superfamily proteins (Kif's) have already been reported.
resultsHere, we report the identification of thirteen kinesin genes exploiting the information from the raw shotgun reads of the Dictyostelium discoideum genome project. A phylogenetic tree of 390 kinesin motor domain sequences was built, grouping the Dictyostelium kinesins into nine subfamilies. According to known cellular functions or strong homologies to kinesins of other organisms, four of the Dictyostelium kinesins are involved in organelle transport, six are implicated in cell division processes, two are predicted to perform multiple functions, and one kinesin may be the founder of a new subclass.
conclusionThis analysis of the Dictyostelium genome led to the identification of eight new kinesin motor proteins. According to an exhaustive phylogenetic comparison, Dictyostelium contains the same subset of kinesins that higher eukaryotes need to perform mitosis. Some of the kinesins are implicated in intracellular traffic and a small number have unpredictable functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.