ArticleThe Biochemical journal2004
PRELI (protein of relevant evolutionary and lymphoid interest) is located within an evolutionarily conserved gene cluster on chromosome 5q34-q35 and encodes a novel mitochondrial protein.
Article in The Biochemical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 25 citations in OpenAlex.
- Phospholipid ebb and flow makes mitochondria go.The Journal of cell biology · 2020Review
- Lipid metabolism-related proteins of relevant evolutionary and lymphoid interest (PRELI) domain containing family proteins in cancer.American journal of translational research · 2020Review
- Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes.EMBO reports · 2015Article
- Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates.Cellular and molecular life sciences : CMLS · 2013Review
- Spare PRELI gene loci: failsafe chromosome insurance?PloS one · 2012Article
- Distinct functions of evolutionary conserved MSF1 and late embryogenesis abundant (LEA)-like domains in mitochondria.The Journal of biological chemistry · 2011Article
- Evolution of the Max and Mlx networks in animals.Genome biology and evolution · 2011Article
- Vital function of PRELI and essential requirement of its LEA motif.Cell death & disease · 2010Article
- Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria.The Journal of cell biology · 2009Article
- Conserved expression of the PRELI domain containing 2 gene (Prelid2) during mid-later-gestation mouse embryogenesis.Journal of molecular histology · 2009Article
- Early vertebrate chromosome duplications and the evolution of the neuropeptide Y receptor gene regions.BMC evolutionary biology · 2008Article
- Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p.The Journal of cell biology · 2006Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The characterization of mitochondrial proteins is important for the understanding of both normal cellular function and mitochondrial disease. In the present study we identify a novel mitochondrial protein, PRELI (protein of relevant evolutionary and lymphoid interest), that is encoded within the evolutionarily conserved MAD3/PRELI/RAB24 gene cluster located at chromosome 5q34-q35. Mouse Preli is expressed at high levels in all settings analysed; it is co-expressed with Rab24 from a strong bi-directional promoter, and is regulated independently from the S-phase-specific Mad3 gene located at its 3' end. PRELI contains a stand-alone 170 amino acid PRELI/MSF1p' motif at its N-terminus. This domain is found in a variety of proteins from diverse eukaryotes including yeast, Drosophila and mammals, but its function is unknown, and the subcellular location of higher eukaryotic PRELI/MSF1P' proteins has not been determined previously. We show here that PRELI is located in the mitochondria, and by using green-fluorescent-protein fusion proteins we identify a mitochondrial targeting signal at its N-terminus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.