ReviewDrug safety2003
Drug interactions between herbal and prescription medicines.
Review in Drug safety, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 167 citations in OpenAlex.
- Prevalence of acquired and transmitted HIV drug resistance in Iran: a systematic review and meta-analysis.BMC infectious diseases · 2024Pooled it
- Interactions between herbal medicines and prescribed drugs: an updated systematic review.Drugs · 2009Pooled it
- Efficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Effects of Botrychium ternatum (Thunb) Sw. On Cytochrome P450 Activities in Rats.Pharmacology research & perspectives · 2025Article
- A comprehensive review of natural compounds and their structure-activity relationship in Parkinson's disease: exploring potential mechanisms.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Diverse Therapeutic Potentials of Hypericin: An In-Depth Review.Current topics in medicinal chemistry · 2025Review
- Phytochemicals, Herbal Extracts, and Dietary Supplements for Metabolic Disease Management.Endocrine, metabolic & immune disorders drug targets · 2025Review
- Sub-acute toxicity evaluation of aqueous leaf extract fromToxicology reports · 2023Article
- Safety Concerns Related to the Simultaneous Use of Prescription or Over-the-Counter Medications and Herbal Medicinal Products: Survey Results among Latvian Citizens.International journal of environmental research and public health · 2023Article
- Herbal supplements in Jordan: a cross-sectional survey of pharmacists' perspectives and knowledge.BMJ open · 2022Article
- Rooibos, a supportive role to play during the COVID-19 pandemic?Journal of functional foods · 2021Review
- An educational intervention improved knowledge of dietary supplements in college students.BMC public health · 2020Article
- Integrating traditional Chinese medicines into professional community pharmacy practice in China - Key stakeholder perspectives.European journal of integrative medicine · 2020Article
- Intravenous lipid emulsion therapy for cardiac arrest and refractory ventricular tachycardia due to multiple herb intoxication.Clinical and experimental emergency medicine · 2019Article
- Prevalence of complementary and alternative medicine use among rheumatoid arthritis patients in Saudi Arabia.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Article
- Community pharmacists' perceptions about pharmaceutical service of over-the-counter traditional Chinese medicine: a survey study in Harbin of China.BMC complementary and alternative medicine · 2017Article
- Elicitation Based Enhancement of Secondary Metabolites in Rauwolfia serpentina and Solanum khasianum Hairy Root Cultures.Pharmacognosy magazine · 2016Article
- Adverse Psychiatric Effects Associated with Herbal Weight-Loss Products.BioMed research international · 2015Review
- Evaluating medicinal plants for anticancer activity.TheScientificWorldJournal · 2014Article
- Decision-making about complementary and alternative medicine by cancer patients: integrative literature review.Open medicine : a peer-reviewed, independent, open-access journal · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Until reports of interactions between St John's wort and drugs such as digoxin, warfarin, protease inhibitors and oral contraceptives began to appear, very few herb-drug interactions were documented. These are now becoming more common, although still rare compared with drug-drug interactions. In the absence of hard data, potential interactions are being highlighted, and this review attempts to distinguish between the speculative and the proven. The subject is approached from a therapeutic point of view since in most cases the patient is already taking one or more prescription drugs, and the question is whether or not it is safe for a particular herb to be added to the regimen. Although many of the examples of herb-drug interactions are minor or theoretical at present, the fact remains that some are serious and life threatening, and these almost exclusively concern cyclosporin, anticoagulants, digoxin, antidepressants and protease inhibitors, taken with the herb St John's wort. Ginkgo and ginseng are implicated in a number of reports, but many of these are unsubstantiated. To date, the cardiovascular, central nervous and immune systems are the most common therapeutic categories cited in the literature and other than those, examples are very limited. Although many herbal drugs have good safety profiles, it must be borne in mind that herbal supplements are intended to be taken over an extended period of time, which provides the opportunity for enzyme induction and other mechanisms of interaction to take effect.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.