ArticleProceedings of the National Academy of Sciences of the United States of America2003
Hox cluster duplications and the opportunity for evolutionary novelties.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
64 citing papers in PubMed, 159 citations in OpenAlex.
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- Piezo3 is a novel mechanosensitive Piezo ion channel in vertebrates.bioRxiv : the preprint server for biology · 2026Article
- Evolution of Highly Repetitive Silk Genes in the Luna Moth, Actias luna.Genome biology and evolution · 2026Article
- Origin and Evolution of Genes in Eukaryotes: Mechanisms, Dynamics, and Functional Implications.Genes · 2025Review
- Zebrafish: unraveling genetic complexity through duplicated genes.Development genes and evolution · 2024Review
- Evolutionary plasticity in nematode Hox gene complements and genomic loci arrangement.Scientific reports · 2024Article
- Sexual size dimorphism in mammals is associated with changes in the size of gene families related to brain development.Nature communications · 2024Article
- Genomic structural variation: A complex but important driver of human evolution.American journal of biological anthropology · 2023Review
- Dual Functions of labial Resolve the Hox Logic of Chelicerate Head Segments.Molecular biology and evolution · 2023Article
- Hox genes in development and beyond.Development (Cambridge, England) · 2023Article
- Early effects of gene duplication on the robustness and phenotypic variability of gene regulatory networks.BMC bioinformatics · 2022Article
- Seeking Sense in the Hox Gene Cluster.Journal of developmental biology · 2022Review
- Gene Recruitments and Dismissals in the Argonaut Genome Provide Insights into Pelagic Lifestyle Adaptation and Shell-like Eggcase Reacquisition.Genome biology and evolution · 2022Article
- HOX-Gene Cluster Organization and Genome Duplications in Fishes and Mammals: Transcript Variant Distribution along the Anterior-Posterior Axis.International journal of molecular sciences · 2022Review
- Regulation of posterior Hox genes by sex steroids explains vertebral variation in inbred mouse strains.Journal of anatomy · 2022Review
- Evolution of inwardly rectifying potassium channels and their gene expression in zebrafish embryos.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Diversification and Functional Evolution of HOX Proteins.Frontiers in cell and developmental biology · 2022Review
- Phylogenetic and developmental analyses indicate complex functions of calcium-activated potassium channels in zebrafish embryonic development.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hox genes play a key role in animal body plan development. These genes tend to occur in tightly linked clusters in the genome. Vertebrates and invertebrates differ in their Hox cluster number, with vertebrates having multiple clusters and invertebrates usually having only one. Recent evidence shows that vertebrate Hox clusters are structurally more constrained than invertebrate Hox clusters; they exclude transposable elements, do not undergo tandem duplications, and conserve their intergenic distances and gene order. These constraints are only relaxed after a cluster duplication. In contrast, invertebrate Hox clusters are structurally more plastic; tandem duplications are common, the linkage of Hox genes can change quickly, or they can lose their structural integrity completely. We propose that the constraints on vertebrate Hox cluster structure lead to an association between the retention of duplicated Hox clusters and adaptive radiations. After a duplication the constraints on Hox cluster structure are temporarily lifted, which opens a window of evolvability for the Hox clusters. If this window of evolvability coincides with an adaptive radiation, chances are that a modified Hox cluster becomes recruited in an evolutionary novelty and then both copies of duplicated Hox clusters are retained.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.