Evidence map›Paper›PMID 14638813›Full record

ArticleInfection and immunity2003

Inducible nitric oxide synthase regulates production of isoprostanes in vivo during chlamydial genital infection in mice.

K H Ramsey, I M Sigar, S V Rana, J Gupta, S M Holland, G I Byrne, J D Morrow

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Inducible nitric oxide synthase inhibitors reduce urinary markers of systemic oxidant stress in murine proliferative lupus nephritis.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2005
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

K H RamseyDepartment of Microbiology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois 60515, USA. kramse@midwestern.edu
I M Sigar
S V Rana
J Gupta
S M Holland
G I Byrne
J D Morrow
Midwestern University · USNational Institutes of Health · USUniversity of Tennessee Health Science Center · USVanderbilt University Medical Center · US

Funding

THE ROLE OF ENDOCANNABINOIDS AND THEIR RECEPTORS IN COLORECTAL CANCERP01CA077839 · NCI · VANDERBILT UNIVERSITY · PI DEY, SUDHANSU K · 1999 to 2016
$17.8M
THE PHARMACOLOGY OF INHIBITORS OF HEME PROTEIN-CATALYZED LIPID PEROXIDATIONP50GM015431 · NIGMS · VANDERBILT UNIVERSITY · PI MARNETT, LAWRENCE J. · 1985 to 2010
$15.0M
Therapeutic Modulation of Endothelial Cell TetrahydrobiopterinP01GM015431 · NIGMS · VANDERBILT UNIVERSITY · PI ROBERTS, II, L JACKSON · 2011 to 2015
$9.5M
IMMUNITY AND LATENCY TO CHLAMYDIAL INFECTIONSR01AI019782 · NIAID · UNIVERSITY OF WISCONSIN MADISON · PI BYRNE, GERALD IRWIN · 1985 to 2014
$4.7M
TRANSGENIC ANIMAL MODELS OF HUMAN IMMUNE DEFECTSZ01AI000646 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI HOLLAND, STEVEN M · 1992 to 2008
$2.4M
BIOCHEMISTRY AND PHARMACOLOGY OF D2/E2-ISOPROSTANESR01DK048831 · NIDDK · VANDERBILT UNIVERSITY · PI YIN, HUIYONG · 1995 to 2008
$2.2M
Host Factors in Susceptibility to Chlamydial DiseaseR01AI049354 · NIAID · MIDWESTERN UNIVERSITY · PI RAMSEY, KYLE H. · 2002 to 2006
$1.0M
NITRIC OXIDE AND CHLAMYDIAL INFECTIONS OF MICER15AI037807 · NIAID · MIDWESTERN UNIVERSITY · PI RAMSEY, KYLE H. · 1996 to 1996
–
NCI NIH HHS CA77839NCI NIH HHS P01 CA077839NIAID NIH HHS AI19782NIAID NIH HHS AI49354NIAID NIH HHS R01 AI019782NIAID NIH HHS R01 AI049354NIAID NIH HHS R15 AI037807NIDDK NIH HHS DK48831NIDDK NIH HHS R01 DK048831NIGMS NIH HHS GM15431NIGMS NIH HHS P01 GM015431NIGMS NIH HHS P50 GM015431
6 · The paper itself

Abstract

Urinary nitrite and F(2)-isoprostanes, an index of oxidant stress, were elevated during chlamydial genital infection of mice. Enhancement of urinary nitrite and F(2)-isoprostanes was observed in phagocyte oxidase-deficient mice. Inhibition of inducible nitric oxide synthase reduced isoprostane excretion. We conclude that nitrogen radicals induce F(2)-isoprostane production and excretion during murine chlamydial genital infection.

Indexed as

Gene Expression RegulationAnimalsChlamydia InfectionsChlamydia trachomatisF2-IsoprostanesFemaleMiceMice, Inbred C57BLMice, KnockoutNitric Oxide SynthaseNitric Oxide Synthase Type IINitritesOxidoreductasesPhagocytesVaginosis, BacterialF2-IsoprostanesNitric Oxide SynthaseNitric Oxide Synthase Type IINitritesNos2 protein, mouseOxidoreductases

Identifiers

PMID14638813
PMCPMC308939
OpenAlexW2097291685

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.