ArticleInfection and immunity2003
Removal of Wolbachia from Brugia pahangi is closely linked to worm death and fecundity but does not result in altered lymphatic lesion formation in Mongolian gerbils (Meriones unguiculatus).
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Assessing the efficacy of high-dose rifampicin plus albendazole against onchocerciasis.PLoS neglected tropical diseases · 2026Trial
- Targeting a microbiotaScience advances · 2024Article
- Review
- Aspartyl Protease Inhibitors as Anti-Filarial Drugs.Pathogens (Basel, Switzerland) · 2022Article
- The Wolbachia Symbiont: Here, There and Everywhere.Results and problems in cell differentiation · 2020Article
- Anti-The Indian journal of medical research · 2019Review
- Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum.PLoS neglected tropical diseases · 2018Article
- Albendazole and antibiotics synergize to deliver short-course anti-Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Antifilarial activity of caffeic acid phenethyl ester on Brugia pahangi in vitro and in vivo.Pathogens and global health · 2017Article
- Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis.Scientific reports · 2016Article
- Brugia pahangi: immunization with early L3 ES alters parasite migration, and reduces microfilaremia and lymphatic lesion formation in gerbils (Meriones unguiculatus).Experimental parasitology · 2013Article
- Effects of doxycycline on gene expression in Wolbachia and Brugia malayi adult female worms in vivo.Journal of biomedical science · 2012Article
- Non-therapeutic administration of a model antimicrobial growth promoter modulates intestinal immune responses.Gut pathogens · 2011Article
- Stage-specific proteomic expression patterns of the human filarial parasite Brugia malayi and its endosymbiont Wolbachia.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Brugia filariasis differentially modulates persistent Helicobacter pylori gastritis in the gerbil model.Microbes and infection · 2010Article
- Diethylcarbamazine and non-diethylcarbamazine related bancroftian granuloma: an immunohistochemical study of eosinophil toxic proteins.International journal of biomedical science : IJBS · 2010Article
- Computational prediction of essential genes in an unculturable endosymbiotic bacterium, Wolbachia of Brugia malayi.BMC microbiology · 2009Article
- Brugia malayi gene expression in response to the targeting of the Wolbachia endosymbiont by tetracycline treatment.PLoS neglected tropical diseases · 2009Article
- Prior killing of intracellular bacteria Wolbachia reduces inflammatory reactions and improves antifilarial efficacy of diethylcarbamazine in rodent model of Brugia malayi.Parasitology research · 2008Article
- Onchocerca parasites and Wolbachia endosymbionts: evaluation of a spectrum of antibiotic types for activity against Onchocerca gutturosa in vitro.Filaria journal · 2006Article
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6 authors.
Funding
Abstract
Approximately 30 years ago, researchers reported intracellular bacteria in filarial nematodes. These bacteria are relatives of the arthropod symbiont Wolbachia and occur in many filarial nematodes, including Brugia pahangi and Brugia malayi. Wolbachia bacteria have been implicated in a variety of roles, including filaria development and fecundity and the pathogenesis of lymphatic lesions associated with filarial infections. However, the role of the bacteria in worm biology or filarial disease is still not clear. The present experiments support previous data showing that tetracycline eliminates or reduces Wolbachia bacteria in B. pahangi in vivo. The elimination of Wolbachia was closely linked to a reduction in female fecundity and the viability of both sexes, suggesting that the killing of Wolbachia is detrimental to B. pahangi. The gerbils treated with tetracycline showed reduced levels of interleukin-4 (IL-4) and IL-5 mRNA in renal lymph nodes and spleens compared with the levels in B. pahangi-infected gerbils not treated with tetracycline. However, similar findings were noted in B. pahangi-infected gerbils treated with ivermectin, suggesting that the loss of circulating microfilariae, not the reduction of Wolbachia bacteria, was associated with the altered cytokine profile. Despite the change in T-cell cytokines, there was no difference in the sizes of renal lymph nodes isolated from gerbils in each treatment group. Furthermore, the numbers, sizes, or cellular compositions of granulomas examined in the lymphatics or renal lymph nodes did not differ with treatment. These data suggest that Wolbachia may not play a primary role in the formation of lymphatic lesions in gerbils chronically infected with B. pahangi.
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