ArticleInfection and immunity2003
Genetic basis for biosynthesis of the (alpha 1-->4)-linked N-acetyl-D-glucosamine 1-phosphate capsule of Neisseria meningitidis serogroup X.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The molecular characteristic of Neisseria meningtidis serogroup X strain emerging in Jiangsu province, China, 2022.BMC microbiology · 2025Article
- Prediction of virulence factors in bacterial hypothetical proteins.Archives of microbiology · 2025Article
- Serogroup A meningococcal conjugate vaccines: building sustainable and equitable vaccine strategies.Expert review of vaccines · 2020Review
- Whole-Genome Sequencing for Characterization of Capsule Locus and Prediction of Serogroup of Invasive Meningococcal Isolates.Journal of clinical microbiology · 2019Article
- Genetic Analysis of Neisseria meningitidis Sequence Type 7 Serogroup X Originating from Serogroup A.Infection and immunity · 2017Article
- Regulation of capsule in Neisseria meningitidis.Critical reviews in microbiology · 2016Review
- Structure and function of the DUF2233 domain in bacteria and in the human mannose 6-phosphate uncovering enzyme.The Journal of biological chemistry · 2013Article
- Description and nomenclature of Neisseria meningitidis capsule locus.Emerging infectious diseases · 2013Article
- Requirement of NMB0065 for connecting assembly and export of sialic acid capsular polysaccharides in Neisseria meningitidis.Microbes and infection · 2010Article
- Stealth proteins: in silico identification of a novel protein family rendering bacterial pathogens invisible to host immune defense.PLoS computational biology · 2005Article
- Viability of a capsule- and lipopolysaccharide-deficient mutant of Neisseria meningitidis.Infection and immunity · 2005Article
- Use of variable-number tandem repeats to examine genetic diversity of Neisseria meningitidis.Journal of clinical microbiology · 2005Article
- Genetic analysis of the capsule locus of Haemophilus influenzae serotype f.Infection and immunity · 2003Article
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Authors and funding
3 authors.
Funding
Abstract
The genetic basis for biosynthesis of the (alpha1-->4)-linked N-acetyl-D-glucosamine 1-phosphate capsule of Neisseria meningitidis serogroup X was defined. The biosynthesis gene cassette was a approximately 4.2-kb region located between ctrA of the capsule transport operon and galE, which encodes the UDP-glucose-4-epimerase. This location was identical to the locations of the biosynthesis cassettes in other meningococcal serogroups. Three open reading frames unique to meningococcus serogroup X were identified. Deletion-insertion mutation and colony immunoblotting confirmed that these three genes were essential for serogroup X capsule expression, and the genes were designated xcbA, xcbB, and xcbC (serogroup X capsule biosynthesis). Reverse transcriptase PCR indicated that the xcbABC genes form an operon and are cotranscribed divergently from ctrA. XcbA exhibited 52% amino acid similarity to SacB, the putative capsule polymerase of meningococcus serogroup A, suggesting that it plays a role as the serogroup X capsule polymerase. An IS1016 element was found within the intergenic region separating ctrA and xcbA in multiple strains, and this element did not interfere with capsule expression.
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