ArticleThe Biochemical journal2004
Glucocorticoids regulate mRNA levels for subunits of the 19 S regulatory complex of the 26 S proteasome in fast-twitch skeletal muscles.
Article in The Biochemical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 75 citations in OpenAlex.
- The effects of ProAlgaZyme novel algae infusion on metabolic syndrome and markers of cardiovascular health.Lipids in health and disease · 2007Trial
- The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome.Lipids in health and disease · 2006Trial
- Role of GLP‑1 receptor agonists in sepsis and their therapeutic potential in sepsis‑induced muscle atrophy (Review).International journal of molecular medicine · 2025Review
- Molecular Mechanisms Underlying Intensive Care Unit-Acquired Weakness and Sarcopenia.International journal of molecular sciences · 2022Review
- A molecule inducing androgen receptor degradation and selectively targeting prostate cancer cells.Life science alliance · 2019Article
- mRNA-seq reveals skeletal muscle atrophy in response to handling stress in a marine teleost, the red cusk-eel (Genypterus chilensis).BMC genomics · 2015Article
- Molecular and cellular mechanisms of skeletal muscle atrophy: an update.Journal of cachexia, sarcopenia and muscle · 2012Article
- Article
- Cardiac proteasome activity in muscle ring finger-1 null mice at rest and following synthetic glucocorticoid treatment.American journal of physiology. Endocrinology and metabolism · 2011Article
- Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids.The Journal of physiology · 2011Article
- Gene expression during normal and FSHD myogenesis.BMC medical genomics · 2011Article
- FOXO3a mediates signaling crosstalk that coordinates ubiquitin and atrogin-1/MAFbx expression during glucocorticoid-induced skeletal muscle atrophy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Time course expression of Foxo transcription factors in skeletal muscle following corticosteroid administration.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats.The Journal of physiology · 2009Article
- Glucocorticoids differentially regulate degradation of MyoD and Id1 by N-terminal ubiquitination to promote muscle protein catabolism.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Roles and potential therapeutic targets of the ubiquitin proteasome system in muscle wasting.BMC biochemistry · 2007Review
- Role of the ubiquitin proteasome system in Parkinson's disease.BMC biochemistry · 2007Review
- Activation of the ubiquitin-proteasome pathway in the diaphragm in chronic obstructive pulmonary disease.American journal of respiratory and critical care medicine · 2006Article
- A leucine-supplemented diet restores the defective postprandial inhibition of proteasome-dependent proteolysis in aged rat skeletal muscle.The Journal of physiology · 2005Article
- Proteolysis in illness-associated skeletal muscle atrophy: from pathways to networks.Critical reviews in clinical laboratory sciencesReview
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circulating levels of glucocorticoids are increased in many traumatic and muscle-wasting conditions that include insulin-dependent diabetes, acidosis, infection, and starvation. On the basis of indirect findings, it appeared that these catabolic hormones are required to stimulate Ub (ubiquitin)-proteasome-dependent proteolysis in skeletal muscles in such conditions. The present studies were performed to provide conclusive evidence for an activation of Ub-proteasome-dependent proteolysis after glucocorticoid treatment. In atrophying fast-twitch muscles from rats treated with dexamethasone for 6 days, compared with pair-fed controls, we found (i) increased MG132-inhibitable proteasome-dependent proteolysis, (ii) an enhanced rate of substrate ubiquitination, (iii) increased chymotrypsin-like proteasomal activity of the proteasome, and (iv) a co-ordinate increase in the mRNA expression of several ATPase (S4, S6, S7 and S8) and non-ATPase (S1, S5a and S14) subunits of the 19 S regulatory complex, which regulates the peptidase and the proteolytic activities of the 26 S proteasome. These studies provide conclusive evidence that glucocorticoids activate Ub-proteasome-dependent proteolysis and the first in vivo evidence for a hormonal regulation of the expression of subunits of the 19 S complex. The results suggest that adaptations in gene expression of regulatory subunits of the 19 S complex by glucocorticoids are crucial in the regulation of the 26 S muscle proteasome.
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