ReviewJournal of mammary gland biology and neoplasia2003
The Nuclear Factor I (NFI) gene family in mammary gland development and function.
Review in Journal of mammary gland biology and neoplasia, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Large-scale genotyping identifies a new locus at 22q13.2 associated with female breast size.Journal of medical genetics · 2013Pooled it
- Coregulators determine androgen receptor activity in prostate cancer.Bioscience reports · 2025Review
- Roles of the NFI/CTF gene family in transcription and development: update 2025.Academia biology · 2025Article
- Distinct regulatory networks control toxin gene expression in elapid and viperid snakes.BMC genomics · 2024Article
- Further characterization of NFIB-associated phenotypes: Report of two new individuals.American journal of medical genetics. Part A · 2023Article
- AFrontiers in pediatrics · 2022Article
- Genome-wide analysis of androgen receptor binding and transcriptomic analysis in mesenchymal subsets during prostate development.Disease models & mechanisms · 2019Article
- Transcription of the Human 5-Hydroxytryptamine Receptor 2B (HTR2B) Gene Is under the Regulatory Influence of the Transcription Factors NFI and RUNX1 in Human Uveal Melanoma.International journal of molecular sciences · 2018Article
- Study of MYB-NFIB chimeric gene expression, tumor angiogenesis, and proliferation in adenoid cystic carcinoma of salivary gland.Odontology · 2018Article
- ERα Binding by Transcription Factors NFIB and YBX1 Enables FGFR2 Signaling to Modulate Estrogen Responsiveness in Breast Cancer.Cancer research · 2018Article
- MicroRNA 373 Facilitates the Replication of Porcine Reproductive and Respiratory Syndrome Virus by Its Negative Regulation of Type I Interferon Induction.Journal of virology · 2017Article
- Nfib Regulates Transcriptional Networks That Control the Development of Prostatic Hyperplasia.Endocrinology · 2016Article
- Nuclear factor one transcription factors: Divergent functions in developmental versus adult stem cell populations.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Review
- Article
- NFI transcription factors interact with FOXA1 to regulate prostate-specific gene expression.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Sulfotransferase 1A1 (SULT1A1) gene expression is regulated by members of the NFI transcription factors in human breast cancer cells.BMC clinical pathology · 2014Article
- Non-overlapping progesterone receptor cistromes contribute to cell-specific transcriptional outcomes.PloS one · 2012Article
- Characterization of cis elements of the probasin promoter necessary for prostate-specific gene expression.The Prostate · 2010Article
- Nuclear factor I transcription factors regulate IGF binding protein 5 gene transcription in human osteoblasts.Biochimica et biophysica acta · 2009Article
- The transcription factor Nfix is essential for normal brain development.BMC developmental biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Mammary gland development and function require the coordinated spatial and temporal expression of a large fraction of the mammalian genome. A number of site-specific transcription factors are essential to achieve the appropriate growth, branching, expansion, and involution of the mammary gland throughout early postnatal development and the lactation cycle. One family of transcription factors proposed to play a major role in the mammary gland is encoded by the Nuclear Factor I (NFI) genes. The NFI gene family is found only in multicellular animals, with single genes being present in flies and worms and four genes in vertebrates. While the NFI family expanded and diversified prior to the evolution of the mammary gland, it is clear that several mammary-gland specific genes are regulated by NFI proteins. Here we address the structure and evolution of the NFI gene family and examine the role of the NFI transcription factors in the expression of mammary-gland specific proteins, including whey acidic protein and carboxyl ester lipase. We discuss current data showing that unique NFI proteins are expressed during lactation and involution and suggest that the NFI gene family likely has multiple important functions throughout mammary gland development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.