ReviewPediatric nephrology (Berlin, Germany)2004
Genetics of hereditary disorders of magnesium homeostasis.
Review in Pediatric nephrology (Berlin, Germany), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pharmacokinetic Study of Mablet as Oral Supplement and Magnesium Sulfate as Infusion
Daily Magnesium-supplement With Mablet for Steroid-resistant, Severe Asthmatics
Metacholine-provocation of Mablet-treated Asthmatics
Daily Mablet-treatment of Patients With COPD
Bilateral Transversus Abdominis Plane Block With or Without Magnesium for Total Abdominal Hysterectomy With or Without Salpingo-oophorectomy: a Randomized Controlled Trial
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Associations Between Serum Magnesium Concentrations and Polycystic Ovary Syndrome Status: a Systematic Review and Meta-analysis.Biological trace element research · 2021Pooled it
- Magnesium and Diabetes: A Review of Recent Studies on the Efficacy of Supplementation with Mg in Humans Suffering from This Chronic Metabolic Disease.International journal of molecular sciences · 2026Review
- Nutritional Factors Affecting Magnesium Bioavailability: A Narrative Review.Biological trace element research · 2026Review
- A pediatric case of hypomagnesemia 1 (HOMG1) caused by novel compound heterozygous mutations inHuman genome variation · 2019Article
- Effects of TRPM7/miR-34a Gene Silencing on Spatial Cognitive Function and Hippocampal Neurogenesis in Mice with Type 1 Diabetes Mellitus.Molecular neurobiology · 2018Article
- Interactions between calcium intake and polymorphisms in genes essential for calcium reabsorption and risk of colorectal neoplasia in a two-phase study.Molecular carcinogenesis · 2017Article
- Sevelamer carbonate reduces the risk of hypomagnesemia in hemodialysis-requiring end-stage renal disease patients.Clinical kidney journal · 2016Article
- Magnesium-permeableSpringerPlus · 2016Article
- Hypomagnesemia and Mortality in Incident Hemodialysis Patients.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2015Observational
- Scientific Opinion on Dietary Reference Values for magnesium.EFSA journal. European Food Safety Authority · 2015Article
- Molecular pathophysiology of Bartter's and Gitelman's syndromes.World journal of pediatrics : WJP · 2015Review
- Calcium intake and ion transporter genetic polymorphisms interact in human colorectal neoplasia risk in a 2-phase study.The Journal of nutrition · 2014Article
- Modifying effect of calcium/magnesium intake ratio and mortality: a population-based cohort study.BMJ open · 2013Article
- Increased expression of renal TRPM6 compensates for Mg(2+) wasting during furosemide treatment.Clinical kidney journal · 2012Article
- Does a higher ratio of serum calcium to magnesium increase the risk for postmenopausal breast cancer?Medical hypotheses · 2010Article
- Function and regulation of claudins in the thick ascending limb of Henle.Pflugers Archiv : European journal of physiology · 2009Review
- Long-term follow-up of a patient with primary hypomagnesaemia and secondary hypocalcaemia due to a novel TRPM6 mutation.European journal of pediatrics · 2009Article
- Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women.BMC medical genetics · 2009Article
- A comparative analysis of the genetic epidemiology of deafness in the United States in two sets of pedigrees collected more than a century apart.American journal of human genetics · 2008Article
- A case of hypomagnesemia with secondary hypocalcemia caused by Trpm6 gene mutation.Indian journal of pediatrics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnesium plays an essential role in many biochemical and physiological processes. Homeostasis of magnesium is tightly regulated and depends on the balance between intestinal absorption and renal excretion. During the last decades, various hereditary disorders of magnesium handling have been clinically characterized and genetic studies in affected individuals have led to the identification of some molecular components of cellular magnesium transport. In addition to these hereditary forms of magnesium deficiency, recent studies have revealed a high prevalence of latent hypomagnesemia in the general population. This finding is of special interest in view of the association between hypomagnesemia and common chronic diseases such as diabetes, coronary heart disease, hypertension, and asthma. However, valuable methods for the diagnosis of body and tissue magnesium deficiency are still lacking. This review focuses on clinical and genetic aspects of hereditary disorders of magnesium homeostasis. We will review primary defects of epithelial magnesium transport, disorders associated with defects in Ca(2+)/ Mg(2+) sensing, as well as diseases characterized by renal salt wasting and hypokalemic alkalosis, with special emphasis on disturbed magnesium homeostasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.