ArticleThe EMBO journal2003
RNA-binding protein Csx1 mediates global control of gene expression in response to oxidative stress.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 78 citations in OpenAlex.
- Article
- Fission yeast Cdc14-like phosphatase Flp1/Clp1 modulates the transcriptional response to oxidative stress.Scientific reports · 2023Article
- miR-589-3p promoted osteogenic differentiation of periodontal ligament stem cells through targeting ATF1.Journal of orthopaedic surgery and research · 2022Article
- Two Novel Dimorphism-Related Virulence Factors ofInternational journal of molecular sciences · 2021Article
- Article
- The Dual-Specificity LAMMER Kinase Affects Stress-Response and Morphological Plasticity in Fungi.Frontiers in cellular and infection microbiology · 2019Review
- Expression of a Structural Protein of the Mycovirus FgV-ch9 Negatively Affects the Transcript Level of a Novel Symptom Alleviation Factor and Causes Virus Infection-Like Symptoms in Fusarium graminearum.Journal of virology · 2018Article
- Identification of factors involved in dimorphism and pathogenicity of Zymoseptoria tritici.PloS one · 2017Article
- Local potentiation of stress-responsive genes by upstream noncoding transcription.Nucleic acids research · 2016Article
- Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.PLoS genetics · 2014Article
- Contributions of transcription and mRNA decay to gene expression dynamics of fission yeast in response to oxidative stress.RNA biology · 2014Article
- RrmA regulates the stability of specific transcripts in response to both nitrogen source and oxidative stress.Molecular microbiology · 2013Article
- Cadmium-induced proteome remodeling regulated by Spc1/Sty1 and Zip1 in fission yeast.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- A comparative transcriptomic analysis of the extremely boron tolerant plant Puccinellia distans with the moderately boron tolerant Gypsophila arrostil.Plant cell reports · 2012Article
- Analysis of stress granule assembly in Schizosaccharomyces pombe.RNA (New York, N.Y.) · 2012Article
- The RNA binding protein Csx1 promotes sexual differentiation in Schizosaccharomyces pombe.PloS one · 2012Article
- Bilobalide protects mitochondrial function in ovariectomized rats by up-regulation of mRNA and protein expression of cytochrome c oxidase subunit I.Journal of molecular neuroscience : MN · 2011Article
- Aspergillus nidulans transcription factor AtfA interacts with the MAPK SakA to regulate general stress responses, development and spore functions.Molecular microbiology · 2011Article
- Phylogenetic and expression analysis of RNA-binding proteins with triple RNA recognition motifs in plants.Molecules and cells · 2011Article
- Cellular stress induces cytoplasmic RNA granules in fission yeast.RNA (New York, N.Y.) · 2011Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Fission yeast Spc1 (Sty1), a stress-activated mitogen-activated protein kinase (MAPK) homologous to human p38, orchestrates global changes in gene expression in response to diverse forms of cytotoxic stress. This control is partly mediated through Atf1, a transcription factor homologous to human ATF2. How Spc1 controls Atf1, and how the cells tailor gene expression patterns to different forms of stress, are unknown. Here we describe Csx1, a novel protein crucial for survival of oxidative but not osmotic stress. Csx1 associates with and stabilizes atf1+ mRNA in response to oxidative stress. Csx1 controls expression of the majority of the genes induced by oxidative stress, including most of the genes regulated by Spc1 and Atf1. These studies reveal a novel mechanism controlling MAPK-regulated transcription factors and suggest how gene expression patterns can be customized to specific forms of stress. Csx1-like proteins in humans may perform similar tasks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.