ArticleGut2003
Bilirubin inhibits bile acid induced apoptosis in rat hepatocytes.
Article in Gut, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 67 citations in OpenAlex.
- Phosphatidylserine induce thrombotic tendency and liver damage in obstructive jaundice.BMC gastroenterology · 2025Article
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- Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury.Communications biology · 2024Article
- PGC-1α is downregulated in a mouse model of obstructive cholestasis but not in a model of liver fibrosis.FEBS open bio · 2021Article
- The In Vivo Antioxidant and Hepatoprotective Actions of Selected Chinese Teas.Foods (Basel, Switzerland) · 2020Article
- Associations between different bilirubin subtypes and diabetic microvascular complications in middle-aged and elderly individuals.Therapeutic advances in endocrinology and metabolism · 2020Article
- In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway.Marine drugs · 2019Article
- Farnesoid X receptor signaling activates the hepatic X-box binding protein 1 pathway in vitro and in mice.Hepatology (Baltimore, Md.) · 2018Article
- The 1-Tosylpentan-3-one Protects against 6-Hydroxydopamine-Induced Neurotoxicity.International journal of molecular sciences · 2017Article
- Rethinking the immune properties of bilirubin in viral hepatitis: from bench to bedside.Clinical & translational immunology · 2015Review
- Distribution of monocyte chemoattractant protein-1 (MCP-1 A-2518G) and chemokine receptor (CCR2-V64Ι) gene variants in hyperbilirubinemic newborns.International journal of clinical and experimental medicine · 2015Article
- Conjugated bilirubin triggers anemia by inducing erythrocyte death.Hepatology (Baltimore, Md.) · 2015Article
- Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperatures.Molecular pharmacology · 2012Article
- Evaluating the beneficial and detrimental effects of bile pigments in early and later life.Frontiers in pharmacology · 2012Article
- Bile acids decrease intracellular bilirubin levels in the cholestatic liver: implications for bile acid-mediated oxidative stress.Journal of cellular and molecular medicine · 2011Article
- Functional induction of the cystine-glutamate exchanger system Xc(-) activity in SH-SY5Y cells by unconjugated bilirubin.PloS one · 2011Article
- Bilirubin, a curse and a boon.Gut · 2003Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsHydrophobic bile acids contribute to hepatocellular injury in cholestasis and rapidly induce apoptosis in vitro; however, unlike Fas agonists, cholestasis does not cause extensive hepatocyte apoptosis. As antioxidants provide protection against bile acid induced liver injury, our premise was that bilirubin, a free radical scavenger with increased plasma levels in the presence of liver disease, could protect hepatocytes against bile acid induced apoptosis.
methodsFreshly isolated rat hepatocytes were incubated for four hours with 100 micromol/l glycochenodeoxycholate (GCDC) alone or with increasing concentrations of unconjugated (UCB) or conjugated (CB) bilirubin.
resultsBoth UCB and CB inhibited GCDC induced apoptosis in a dose dependent fashion and suppressed the generation of reactive oxygen species by hepatocytes.
conclusionsThe antiapoptotic effect of bilirubin associated with its antioxidant properties indicates that hyperbilirubinaemia may have a protective role in liver disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.