ArticleThe American journal of pathology2003
Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- The Critical Role of Inhibitor of Differentiation 4 in Breast Cancer: From Mammary Gland Development to Tumor Progression.Cancer medicine · 2025Review
- Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer.Breast cancer research : BCR · 2020Article
- Combating subclonal evolution of resistant cancer phenotypes.Nature communications · 2017Article
- Article
- Id4 dependent acetylation restores mutant-p53 transcriptional activity.Molecular cancer · 2013Article
- Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN.Molecular cancer · 2013Article
- Epigenetic inactivation of inhibitor of differentiation 4 (Id4) correlates with prostate cancer.Cancer medicine · 2012Article
- The biology of progesterone receptor in the normal mammary gland and in breast cancer.Molecular and cellular endocrinology · 2012Review
- Article
- Inhibitor of DNA binding-4 promotes angiogenesis and growth of glioblastoma multiforme by elevating matrix GLA levels.Oncogene · 2010Article
- ID4: a new player in the cancer arena.Oncotarget · 2010Article
- Gene expression profiling in the lung tissue of cynomolgus monkeys in response to repeated exposure to welding fumes.Archives of toxicology · 2010Article
- The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis.Nature structural & molecular biology · 2009Article
- Inhibitor of differentiation 4 (Id4) is a potential tumor suppressor in prostate cancer.BMC cancer · 2009Article
- USF1/2 transcription factor DNA-binding activity is induced during rat Sertoli cell differentiation.Biology of reproduction · 2009Article
- Transcriptional response of the murine mammary gland to acute progesterone exposure.Endocrinology · 2008Article
- Image-based evaluation of the molecular events underlying HC11 mammary epithelial cell differentiation.Analytical biochemistry · 2008Article
- [Promoter methylation of ID4. A marker for recurrence-free survival in human breast cancer].Der Pathologe · 2008Article
- Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer.BMC cancer · 2008Article
- Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer.Oncogene · 2005Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Id4 belongs to a family of helix-loop-helix (HLH) proteins that impact cellular growth and differentiation via regulation of basic HLH transcription factors. Herein the rat Id4 gene was cloned (GenBank Accession No. AF468681). The expression of rat Id4 was examined in rat mammary gland tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a carcinogen found in the human diet. By real-time polymerase chain reaction analysis, relative expression of Id4 mRNA in carcinomas, adenomas, and normal tissue was 27, 6, and 1, respectively. Immunohistochemical analysis indicated statistically elevated nuclear expression for Id4 protein in carcinomas in comparison to adenomas and normal mammary gland. In carcinomas, Id4 nuclear expression was positively correlated with proliferation, invasiveness, and tumor weight (Fisher Exact Test or Spearman Correlation, P < 0.05). The consequence of enforced expression of Id4 on mammary epithelial cell proliferation, differentiation, and growth in soft agar was examined in HC11 cells, a well-characterized model for studying various aspects of mammary epithelial cell biology. After transient and stable transfection of HC11 cells, Id4 overexpression increased cell proliferation and inhibited lactogenic hormone-mediated differentiation as revealed by inhibition of beta-casein promoter activity and beta-casein expression. In addition, enforced expression of Id4 in HC11 cells induced a statistically significant increase in colony growth in soft agar. The results implicate Id4 in rat mammary gland carcinogenesis and suggest that Id4 may contribute to carcinogenesis by inhibiting mammary epithelial cell differentiation and stimulating mammary epithelial cell growth.
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