ArticleThe American journal of pathology2003
Amphiregulin overexpression results in rapidly growing keratinocytic tumors: an in vivo xenograft model of keratoacanthoma.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Loss of Rab25 promotes the development of skin squamous cell carcinoma through the dysregulation of integrin trafficking.The Journal of pathology · 2019Article
- Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway.Scientific reports · 2018Article
- Membrane-Tethered Intracellular Domain of Amphiregulin Promotes Keratinocyte Proliferation.The Journal of investigative dermatology · 2016Article
- Epidermal growth factor signaling in transformed cells.International review of cell and molecular biology · 2015Review
- Article
- High-amylose resistant starch increases hormones and improves structure and function of the gastrointestinal tract: a microarray study.Journal of nutrigenetics and nutrigenomics · 2012Article
- Molecular analysis of tumor-promoting CD8+ T cells in two-stage cutaneous chemical carcinogenesis.The Journal of investigative dermatology · 2010Article
- CXCR3/ligands are significantly involved in the tumorigenesis of basal cell carcinomas.The American journal of pathology · 2010Article
- Amphiregulin as a novel target for breast cancer therapy.Journal of mammary gland biology and neoplasia · 2008Review
- Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively.Oncogene · 2006Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Keratoacanthoma (KA) is a variant of cutaneous squamous cell carcinoma (SCC) known for rapid growth and potential for involution. Little is known about the basis for the rapid growth because of the dearth of model systems. We hypothesized that amphiregulin (AR), a keratinocyte autocrine growth factor, had a significant role. Using immunohistochemistry, we compared 21 KA, 6 conventional SCC, and 6 basal cell carcinomas (BCC) for AR expression. All KA were positive for AR, the majority with strong immunoreactivity. The SCC were positive (5 of 6), with generally weak staining; no BCC were positive. We developed laboratory model systems to study AR overexpression in keratinocytes and its role in the pathogenesis of KA. A retroviral transduction strategy was used to overexpress AR in the HaCaT keratinocyte-like cell line. The AR overexpressing cells (HaCaT-AR) displayed autonomous proliferation in serum-free media when compared with controls (HaCaT-NIE). To develop an in vivo model, xenografts of HaCaT-AR and HaCaT-NIE were grown on SCID mice. The HaCaT-NIE cells formed thin tumors resembling conventional SCC. The HaCaT-AR cells formed rapidly growing tumors with AR expression similar to KA. HaCaT-AR cells may represent a new system for the further evaluation of KA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.