ArticleClinical and experimental immunology2003
Differential major histocompatibility complex class II locus expression on human laryngeal epithelium.
Article in Clinical and experimental immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 47 citations in OpenAlex.
- Synergistic Effects of SDS and HInternational journal of biomaterials · 2024Article
- The characteristics of upper airway edema in hereditary and acquired angioedema with C1-inhibitor deficiency.Clinical and translational allergy · 2021Article
- Laryngeal T regulatory cells in the setting of smoking and reflux.The Laryngoscope · 2017Article
- A Novel Model on DST-Induced Transplantation Tolerance by the Transfer of Self-Specific Donor tTregs to a Haplotype-Matched Organ Recipient.Frontiers in immunology · 2017Article
- MHC class II genes in the European badger (Meles meles): characterization, patterns of variation, and transcription analysis.Immunogenetics · 2012Article
- Contributions of humoral and cellular immunity to vaccine-induced protection in humans.Virology · 2011Review
- At the crossroads: mucosal immunology of the larynx.Mucosal immunology · 2009Review
- The mucosal immune response to laryngopharyngeal reflux.American journal of respiratory and critical care medicine · 2008Article
- From grunts to words: experiments in laryngeal transplantation.Annals of the Royal College of Surgeons of England · 2007Article
- Early immunological changes associated with laryngeal transplantation in a major histocompatibility complex-matched pig model.Clinical and experimental immunology · 2006Article
- Major histocompatibility complex class I expression in human tonsillar and laryngeal epithelium.Clinical and experimental immunology · 2006Article
- The larynx as an immunological organ: immunological architecture in the pig as a large animal model.Clinical and experimental immunology · 2006Article
- Reconstructive procedures for impaired upper airway function: laryngeal respiration.GMS current topics in otorhinolaryngology, head and neck surgery · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The survival of a laryngeal allograft will be dependent on the immunological composition of the donor larynx and, in particular, on the expression of major histocompatibility complex (MHC) class II antigens on professional and non-professional antigen-presenting cells. Laryngeal and tonsillar biopsies from normal individuals aged 18-78 years were processed and prepared for quantitative, multiple-colour immunofluorescence using mouse antihuman monoclonal antibodies to human leucocyte antigen (HLA)-DR, HLA-DQ and CD45. The laryngeal epithelium expressed HLA-DR locus products at variable levels, but expression of HLA-DQ was virtually absent. Tonsillar epithelial cells expressed HLA-DR at the basal layer only, while HLA-DQ was similarly not expressed. In contrast, both HLA-DR and -DQ locus products were present on lamina propria and intraepithelial leucocytes in both laryngeal and tonsillar mucosae, although at varying levels. The finding that laryngeal epithelial cells express MHC class II antigens has implications for the survival of laryngeal allografts and suggests that they may require significant immunomodulation. In addition, antigen presentation by epithelial cells has been hypothesized to contribute to the immunoregulatory function of mucosal tissues, and the finding that HLA-DQ locus products are only expressed at low levels by laryngeal epithelium raises questions about the repertoire of peptides to which the mucosal immune system can respond.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.