ArticleClinical and experimental immunology2003
Loss of the CD56hiCD16- NK cell subset and NK cell interferon-gamma production during antiretroviral therapy for HIV-1: partial recovery by human growth hormone.
Article in Clinical and experimental immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Low-dose growth hormone for 40 weeks induces HIV-1-specific T cell responses in patients on effective combination anti-retroviral therapy.Clinical and experimental immunology · 2013Trial
- The reconstitution of the thymus in immunosuppressed individuals restores CD4-specific cellular and humoral immune responses.Immunology · 2011Trial
- NK Cells Engineered with a Chimeric Antigen Receptor Delay HIV Rebound and Reshape HIV Reservoir Composition.bioRxiv : the preprint server for biology · 2026Article
- Early antiretroviral therapy and its impact on natural killer cell dynamics in HIV-1 infected men who have sex with men: a cross-sectional pilot study evaluating the impact of early ART initiation on NK cell perturbation in HIV infection.Microbiology spectrum · 2024Article
- Current Advances in Humanized Mouse Models for Studying NK Cells and HIV Infection.Microorganisms · 2023Review
- Latency reversal plus natural killer cells diminish HIV reservoir in vivo.Nature communications · 2022Article
- The Impact of Growth Hormone Therapy on the Apoptosis Assessment in CD34+ Hematopoietic Cells from Children with Growth Hormone Deficiency.International journal of molecular sciences · 2017Article
- Alterations of the NK cell pool in HIV/HCV co-infection.PloS one · 2017Article
- Role of Natural Killer Cells in HIV-Associated Malignancies.Frontiers in immunology · 2017Review
- HIV patients stable on ART retain evidence of a high CMV load but changes to Natural Killer cell phenotypes reflect both HIV and CMV.AIDS research and therapy · 2015Article
- The natural killer cell interferon-gamma response to bacteria is diminished in untreated HIV-1 infection and defects persist despite viral suppression.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Involvement of activating NK cell receptors and their modulation in pathogen immunity.Journal of biomedicine & biotechnology · 2011Review
- Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways.Current opinion in pharmacology · 2010Review
- NK cells in HIV-1 infection: evidence for their role in the control of HIV-1 infection.Journal of internal medicine · 2009Review
- Effects of recombinant human growth hormone on HIV-1-specific T-cell responses, thymic output and proviral DNA in patients on HAART: 48-week follow-up.Journal of immune based therapies and vaccines · 2008Article
- Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- NKG2C+ NK cells are enriched in AIDS patients with advanced-stage Kaposi's sarcoma.Journal of virology · 2007Article
- Dendritic cells and natural killer cells in the pathogenesis of HIV infection.Immunologic research · 2005Review
- Neuroendocrine hormones such as growth hormone and prolactin are integral members of the immunological cytokine network.Cellular immunologyReview
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies have shown that human natural killer (NK) cells are lost from the periphery and are functionally suppressed during HIV-1 infection, and that the administration of highly active antiretroviral therapy (HAART) results in a recovery of NK cell numbers in HIV-1-infected individuals. However, despite this recovery, interleukin (IL)-2 + IL-12-driven interferon (IFN)-gamma production by NK cells has been shown to remain suppressed after HAART. Here we show that the innate immune factor IL-15 in combination with IL-12 is also unable to recover NK cell IFN-gamma production in HAART-treated individuals. Furthermore, we also demonstrate an imbalance in the distribution of CD56loCD16hi and CD56hiCD16- NK subsets after successful HAART, CD56hiCD16- cells being reduced substantially in HIV-1 patients on HAART. Treatment of patients with combined human growth hormone and antiretroviral therapy resulted in further enhancement in the absolute numbers and the proportion of NK cells in some individuals in the absence of parallel effects on CD4+ T cells. Furthermore, in these individuals HAART with growth hormone resulted in an enhancement of cytokine-driven NK cell activation and IFN-gamma production compared to the HAART-only baseline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.