ArticleInternational journal of experimental pathology2003
Diverse range of fixed positional deformities and bone growth restraint provoked by flaccid paralysis in embryonic chicks.
Article in International journal of experimental pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Immobilization secondary to cell death of muscle precursors with a dual transcriptional signature contributes to the emu wing skeletal pattern.Nature communications · 2024Article
- The Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis.Calcified tissue international · 2021Review
- Onset of neonatal locomotor behavior and the mechanical development of Achilles and tail tendons.Journal of biomechanics · 2019Article
- Effect of grape seed extract on maternal toxicity and in utero development in mice treated with zearalenone.Environmental science and pollution research international · 2019Article
- Molecular and cellular mechanisms underlying the evolution of form and function in the amniote jaw.EvoDevo · 2019Review
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- TiOScientific reports · 2018Article
- The role of embryo movement in the development of the furcula.Journal of anatomy · 2017Article
- Limb proportions show developmental plasticity in response to embryo movement.Scientific reports · 2017Article
- Recognizing the Common Origins of Dystonia and the Development of Human Movement: A Manifesto of Unmet Needs in Isolated Childhood Dystonias.Frontiers in neurology · 2016Article
- Mechanical activation of mammalian target of rapamycin pathway is required for cartilage development.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Mechanoadaptation of developing limbs: shaking a leg.Journal of anatomy · 2014Review
- Cartilage to bone transitions in health and disease.The Journal of endocrinology · 2013Review
- Mechanical factors in embryonic tendon development: potential cues for stem cell tenogenesis.Current opinion in biotechnology · 2013Review
- Swim-training changes the spatio-temporal dynamics of skeletogenesis in zebrafish larvae (Danio rerio).PloS one · 2012Article
- Cartilage biology in osteoarthritis--lessons from developmental biology.Nature reviews. Rheumatology · 2011Review
- Article
- Non-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fate.PloS one · 2009Article
- Early effects of embryonic movement: 'a shot out of the dark'.Journal of anatomy · 2006Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancuronium bromide (PB) is used in neonates and pregnant women to induce limp, flaccid paralysis in order to allow mechanical ventilation during intensive care. Such non-depolarizing neuromuscular blocking drugs are administered to 0.1% of all human births in the UK. In this study, we examined PB effects on skeletal development in chick embryos. PB treatment produced skeletal deformities associated with significant reduction in longitudinal growth of all appendicular elements. This was associated with greater cartilage to bone ratios, indicating a preferential reduction in osteogenesis. PB also increased the incidence of knee joint flexion and tibiotarsal joint hyperextension. In addition to limb, spinal and craniofacial deformities, flaccid immobility appears to convert the normal geometric pattern of weight gain to a simple arithmetic accretion. This novel study highlights the potentially harmful effects of pharmacologically induced flaccid immobility on chick embryonic skeletal development. Whilst in ovo avian development clearly differs from human, our findings may have implications for the fetus, premature and term neonate receiving such non-depolarizing neuromuscular blocking drugs.
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