ArticleAmerican journal of human genetics2003
Informativeness of genetic markers for inference of ancestry.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 322 papers.
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322 citing papers in PubMed.
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- Genome-wide characterization of genetic diversity and breed discrimination markers in Tharparkar cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Reflections on the Human Genome Diversity Project: a conversation with Marcus W. Feldman, Henry T. Greely, and Mary-Claire King.Genetics · 2026Article
- Genetic data and population structure of 10 DIP-STR markers across four US population groups.International journal of legal medicine · 2026Article
- Facilitating genomic breeding in citrus via reference panel-based whole-genome imputation of low-coverage sequencing-derived genotype data.Breeding science · 2026Article
- Genetic structure analysis of a Northwest Chinese population using a self-developed DIP system and machine learning for forensic ancestry inference.BMC genomics · 2026Article
- Development of High-Throughput Genomic Resources to Inform White-Tailed Deer Population and Disease Management.Molecular ecology resources · 2026Article
- Performance of a self-developed panel for biogeographic ancestry inference and dissection of the genetic background of three Tibetan groups.Hereditas · 2025Article
- Assessment of a microhaplotype panel for human identification and ancestry inference in Brazil.International journal of legal medicine · 2025Article
- Integrated genetic and geographic ancestry prediction via large-scale genomic data and machine learning.Human genomics · 2025Article
- Efficiency of Ancestral Inference and Characterization of Genetic Structure of Chinese Kazakh Group with a Novel InDel Panel.Journal of molecular evolution · 2025Article
- An Intergeneric Hybrid Between Historically Isolated Temperate and Tropical Jays Following Recent Range Expansion.Ecology and evolution · 2025Article
- Bioinformatic insights into five Chinese population substructures inferred from the East Asian-specific AISNP panel.BMC genomics · 2025Article
- A high-throughput screening method for selecting feature SNPs to evaluate breed diversity and infer ancestry.Genome research · 2025Article
- Article
- triangulaR: an R package for identifying AIMs and building triangle plots using SNP data from hybrid zones.Heredity · 2025Article
- A Pipeline and Recommendations for Population and Individual Diagnostic SNP Selection in Non-Model Species.Molecular ecology resources · 2025Article
262 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
Inference of individual ancestry is useful in various applications, such as admixture mapping and structured-association mapping. Using information-theoretic principles, we introduce a general measure, the informativeness for assignment (I(n)), applicable to any number of potential source populations, for determining the amount of information that multiallelic markers provide about individual ancestry. In a worldwide human microsatellite data set, we identify markers of highest informativeness for inference of regional ancestry and for inference of population ancestry within regions; these markers, which are listed in online-only tables in our article, can be useful both in testing for and in controlling the influence of ancestry on case-control genetic association studies. Markers that are informative in one collection of source populations are generally informative in others. Informativeness of random dinucleotides, the most informative class of microsatellites, is five to eight times that of random single-nucleotide polymorphisms (SNPs), but 2%-12% of SNPs have higher informativeness than the median for dinucleotides. Our results can aid in decisions about the type, quantity, and specific choice of markers for use in studies of ancestry.
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