ReviewJournal of psychiatry & neuroscience : JPN2003
Molecular genetics of schizophrenia: a critical review.
Review in Journal of psychiatry & neuroscience : JPN, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Eye movement dysfunction in first-degree relatives of patients with schizophrenia: a meta-analytic evaluation of candidate endophenotypes.Brain and cognition · 2008Pooled it
- Accumulation of Carbonyl Proteins in the Brain of Mouse Model for Methylglyoxal Detoxification Deficits.Antioxidants (Basel, Switzerland) · 2021Article
- MiRNAs of peripheral blood as the biomarker of schizophrenia.Hereditas · 2018Review
- Theranostic Biomarkers for Schizophrenia.International journal of molecular sciences · 2017Review
- Visualization analysis of author collaborations in schizophrenia research.BMC psychiatry · 2015Article
- Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics.International journal of Alzheimer's disease · 2012Article
- Genomics and pharmacogenomics of dementia.CNS neuroscience & therapeutics · 2011Review
- Multiple transcriptional mechanisms control Ptf1a levels during neural development including autoregulation by the PTF1-J complex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- The myelin-pathogenesis puzzle in schizophrenia: a literature review.Molecular psychiatry · 2008Review
- NCAM1 association study of bipolar disorder and schizophrenia: polymorphisms and alternatively spliced isoforms lead to similarities and differences.Psychiatric genetics · 2007Article
- Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia.Molecular psychiatry · 2006Article
- Effects of population structure and sex on association between serotonin receptors and Drosophila heart rate.Genetics · 2004Article
- Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia.BMC psychiatry · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present an overview of current progress and future directions in the molecular genetics of schizophrenia. We review linkage studies, involving the genome-wide scan of chromosomes with closely spaced polymorphic markers, and association studies of candidate genes, identified on the basis of receptors, neurotransmitters and response to certain drugs. The limitations of the research methodology involved in analyzing such a complex disorder are discussed, as are methods to strengthen this methodology with newer statistical and technological advances to give results that are replicable, statistically significant and applicable to a wider population. A greater understanding of the genetic mechanisms and the application of pharmacogenetics would lead to improvements in therapeutic interventions.
Indexed as
Identifiers
14631454PMC257788What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.