ArticleThe Plant cell2003
Poplar metal tolerance protein 1 confers zinc tolerance and is an oligomeric vacuolar zinc transporter with an essential leucine zipper motif.
Article in The Plant cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 200 citations in OpenAlex.
- Vacuolar zinc transporter TaMTP1 safeguards wheat fertility and regulates grain zinc allocation via stem-mediated sequestration.The Plant journal : for cell and molecular biology · 2026Article
- Identification and Characterization of Dmct: A Cation Transporter inJournal of fungi (Basel, Switzerland) · 2023Article
- PcNRAMP1 Enhances Cadmium Uptake and Accumulation inInternational journal of molecular sciences · 2022Article
- Duplication of NRAMP3 gene in poplars generated two homologous transporters with distinct functions.Molecular biology and evolution · 2022Article
- Identification and functional analysis of cation-efflux transporter 1 from Brassica juncea L.BMC plant biology · 2022Article
- Metal Tolerance Protein Encoding Gene Family inPlants (Basel, Switzerland) · 2022Article
- The E3 Ubiquitin Ligase GeneAntioxidants (Basel, Switzerland) · 2022Article
- Genome-Wide Identification, Structure Characterization, Expression Pattern Profiling, and Substrate Specificity of the Metal Tolerance Protein Family inPlants (Basel, Switzerland) · 2021Article
- An improved and efficient method of Agrobacterium syringe infiltration for transient transformation and its application in the elucidation of gene function in poplar.BMC plant biology · 2021Article
- Modulation of Key Physio-Biochemical and Ultrastructural Attributes after Synergistic Application of Zinc and Silicon on Rice under Cadmium Stress.Plants (Basel, Switzerland) · 2021Article
- Characterization of Brassica rapa metallothionein and phytochelatin synthase genes potentially involved in heavy metal detoxification.PloS one · 2021Article
- Genome-Wide Identification of Metal Tolerance Protein Genes inInternational journal of molecular sciences · 2020Article
- Effects of Exogenous Organic Acids on Cd Tolerance Mechanism ofFrontiers in plant science · 2020Article
- PuHSFA4a Enhances Tolerance To Excess Zinc by Regulating Reactive Oxygen Species Production and Root Development inPlant physiology · 2019Article
- Genome-wide identification and characterization of the metal tolerance protein (MTP) family in grape (3 Biotech · 2019Article
- Implications for Cation Selectivity and Evolution by a Novel Cation Diffusion Facilitator Family Member From the Moderate HalophileFrontiers in microbiology · 2019Article
- Systemic Upregulation of MTP2- and HMA2-Mediated Zn Partitioning to the Shoot Supplements Local Zn Deficiency Responses.The Plant cell · 2018Article
- Vacuolar zinc transporter Zrc1 is required for detoxification of excess intracellular zinc in the human fungal pathogen Cryptococcus neoformans.Journal of microbiology (Seoul, Korea) · 2018Article
- MtMTP2-Facilitated Zinc Transport Into Intracellular Compartments Is Essential for Nodule Development inFrontiers in plant science · 2018Article
- OsMTP11 is localised at the Golgi and contributes to Mn tolerance.Scientific reports · 2017Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cation diffusion facilitator (CDF) proteins are a recently discovered family of cation efflux transporters that might play an essential role in metal homeostasis and tolerance. Here, we describe the identification, characterization, and localization of PtdMTP1, a member of the CDF family from the hybrid poplar Populus trichocarpa x Populus deltoides. PtdMTP1 is expressed constitutively and ubiquitously, although at low levels. Heterologous expression in yeast showed that PtdMTP1 was able to complement the hypersensitivity of mutant strains to Zn but not to other metals, including Cd, Co, Mn, and Ni. PtdMTP1 fused to green fluorescent protein localized to the vacuolar membrane both in yeast and in plant cells, consistent with a function of PtdMTP1 in zinc sequestration. Overexpression of PtdMTP1 in Arabidopsis confers Zn tolerance. We show that PtdMTP1, when expressed in yeast and Arabidopsis, forms homooligomers, a novel feature of CDF members. Oligomer formation is disrupted by reducing agents, indicating possible disulfide bridge formation. PtdMTP1 also contains a conserved Leu zipper motif. Although not necessary for oligomer formation, Leu residues within this motif are required for PtdMTP1 functional activity.
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