ArticleGenes & development2003
Regulation of Polycomb group complexes by the sequence-specific DNA binding proteins Zeste and GAGA.
Article in Genes & development, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Hexavalent chromium-induced epigenetic instability and transposon activation lead to phenotypic variations and tumors inEnvironmental epigenetics · 2023Article
- Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells.eLife · 2021Article
- Polycomb Assemblies Multitask to Regulate Transcription.Epigenomes · 2019Review
- The Hox transcription factor Ubx stabilizes lineage commitment by suppressing cellular plasticity ineLife · 2019Article
- Phylogenetic Analyses and GAGA-Motif Binding Studies of BBR/BPC Proteins Lend to Clues in GAGA-Motif Recognition and a Regulatory Role in Brassinosteroid Signaling.Frontiers in plant science · 2019Article
- Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness inDevelopment (Cambridge, England) · 2018Article
- Global changes of H3K27me3 domains and Polycomb group protein distribution in the absence of recruiters Spps or Pho.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The Hox proteins Ubx and AbdA collaborate with the transcription pausing factor M1BP to regulate gene transcription.The EMBO journal · 2017Article
- Article
- The Arabidopsis GAGA-Binding Factor BASIC PENTACYSTEINE6 Recruits the POLYCOMB-REPRESSIVE COMPLEX1 Component LIKE HETEROCHROMATIN PROTEIN1 to GAGA DNA Motifs.Plant physiology · 2015Article
- Integrating motif, DNA accessibility and gene expression data to build regulatory maps in an organism.Nucleic acids research · 2015Article
- New insights for Drosophila GAGA factor in larvae.Royal Society open science · 2015Article
- High-resolution mapping defines the cooperative architecture of Polycomb response elements.Genome research · 2014Article
- Architectural and functional diversity of polycomb group response elements in Drosophila.Genetics · 2013Article
- Drosophila GAGA factor polyglutamine domains exhibit prion-like behavior.BMC genomics · 2013Article
- A novel human polycomb binding site acts as a functional polycomb response element in Drosophila.PloS one · 2012Article
- Molecular genetic analysis of Suppressor 2 of zeste identifies key functional domains.Genetics · 2009Article
- The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation.Genes & development · 2009Article
- Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells.PloS one · 2008Article
- Dietary manipulation of histone structure and function.Annual review of nutrition · 2008Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Repression and activation of the expression of homeotic genes are maintained by proteins encoded by the Polycomb group (PcG) and trithorax group (trxG) genes. Complexes formed by these proteins are targeted by PcG or trxG response elements (PREs/TREs), which share binding sites for several of the same factors. GAGA factor and Zeste bind specifically to PREs/TREs and have been shown to act as both activators and repressors. We have used purified proteins and complexes reconstituted from recombinant subunits to characterize the effects of GAGA and Zeste proteins on PcG function using a defined in vitro system. Zeste directly associates with the PRC1 core complex (PCC) and enhances the inhibitory activity of this complex on all templates, with a preference for templates with Zeste binding sites. GAGA does not stably associate with PCC, but nucleosomal templates bound by GAGA are more efficiently bound and more efficiently inhibited by PCC. Thus Zeste and GAGA factor use distinct means to increase repression mediated by PRC1.
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