ArticleAmerican journal of human genetics1992
The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, Minnesota. II. Regression relationships with concomitants.
Article in American journal of human genetics, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Epidemiology of Atherosclerosis
Sodium Transport: Genetics and Hypertension
Genetic Epidemiology of Coronary Heart Disease
Who cites it
14 citing papers in PubMed.
- Age, APOE and sex: Triad of risk of Alzheimer's disease.The Journal of steroid biochemistry and molecular biology · 2016Review
- Association of polymorphisms in NOS3 with the ankle-brachial index in hypertensive adults.Atherosclerosis · 2008Article
- Gender- and age-specific contributions of additional DNA sequence variation in the 5' regulatory region of the APOE gene to prediction of measures of lipid metabolism.Human genetics · 2004Article
- Risk and protective effects of the APOE gene towards Alzheimer's disease in the Kungsholmen project: variation by age and sex.Journal of neurology, neurosurgery, and psychiatry · 2004Article
- Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolism.American journal of human genetics · 2002Article
- A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation.Genome research · 2001Article
- Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism.American journal of human genetics · 2000Article
- Evidence that the apolipoprotein E-genotype effects on lipid levels can change with age in males: a longitudinal analysis.American journal of human genetics · 1997Article
- Genotype-environment interaction: apolipoprotein E (ApoE) gene effects and age as an index of time and spatial context in the human.Genetics · 1996Article
- Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City.American journal of human genetics · 1996Article
- Apolipoprotein E and Alzheimer's disease: the implications of progress in molecular medicine.American journal of public health · 1995Review
- Screening for naturally occurring apolipoprotein A-I variants: apo A-I(delta K107) is associated with low HDL-cholesterol levels in men but not in women.Human genetics · 1995Article
- The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, MN. III. Correlations and covariances.American journal of human genetics · 1994Article
- Analysis of systems influencing renal hemodynamics and sodium excretion. I. Biochemical systems theory.Integrative physiological and behavioral science : the official journal of the Pavlovian SocietyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The influence of the apolipoprotein E (Apo E) polymorphism and gender on the regression relationships between each of nine plasma lipid and apolipoprotein traits (total cholesterol; ln triglycerides; high-density-lipoprotein cholesterol; apolipoproteins AI, AII, B, and CII; ln CIII; and ln E) and four concomitants (age, weight, waist-to-hip ratio, and smoking) was studied in 507 unrelated individuals representative of the adult population of Rochester, MN. Analyses are presented separately for females and males. Each lipid and apolipoprotein trait exhibited at least one Apo E genotype-specific regression relationship with the concomitants investigated in this study. In most cases the heterogeneity of regression was associated with differences between the epsilon 32 and epsilon 33 genotype. This study documents that the influence of Apo E genotype on average levels of plasma lipids and apolipoproteins varies among subdivisions of the population defined by age, body size, and smoking status.
Indexed as
Identifiers
1463013PMC1682931What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.