ArticleMammalian genome : official journal of the International Mammalian Genome Society2003
Prospects for whole genome linkage disequilibrium mapping in domestic dog breeds.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 29 citations in OpenAlex.
- Heritability and genome-wide association study of vaccine-induced immune response in Beagles: A pilot study.Vaccine · 2024Article
- Genomic association and further characterisation of faecal immunoglobulin A deficiency in German Shepherd dogs.Veterinary medicine and science · 2021Article
- Whole-genome linkage disequilibrium screening for complex traits in horses.Molecular genetics and genomics : MGG · 2007Article
- Finding cardiovascular disease genes in the dog.Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology · 2006Article
- Modeling extent and distribution of zygotic disequilibrium: implications for a multigenerational canine pedigree.Genetics · 2006Article
- Canine genomics and genetics: running with the pack.PLoS genetics · 2005Review
- Extensive and breed-specific linkage disequilibrium in Canis familiaris.Genome research · 2004Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Linkage disequilibrium (LD) mapping is commonly used as a fine mapping tool in human genome mapping and has been used with some success for initial disease gene isolation in certain isolated in-bred human populations. An understanding of the population history of domestic dog breeds suggests that LD mapping could be routinely utilized in this species for initial genome-wide scans. Such an approach offers significant advantages over traditional linkage analysis. Here, we demonstrate, using canine copper toxicosis in the Bedlington terrier as the model, that LD mapping could be reasonably expected to be a useful strategy in low-resolution, genome-wide scans in pure-bred dogs. Significant LD was demonstrated over distances up to 33.3 cM. It is very unlikely, for a number of reasons discussed, that this result could be extrapolated to the rest of the genome. It is, however, consistent with the expectation given the population structure of canine breeds and, in this breed at least, with the hypothesis that it may be possible to utilize LD in a genome-wide scan. In this study, LD mapping confirmed the location of the copper toxicosis in Bedlington terrier gene (CT-BT) and was able to do so in a population that was refractory to traditional linkage analysis.
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