ArticleJournal of molecular evolution2003
Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen.
Article in Journal of molecular evolution, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 86 citations in OpenAlex.
- Pervasive relaxed selection on spermatogenesis genes coincident with the evolution of polygyny in gorillas.eLife · 2026Article
- Comparative functional analyses of the prostate-specific KLK3 enzyme in primates reveal the impact of sexual selection.Evolution; international journal of organic evolution · 2025Article
- Indirect evidence of an early mating advantage in wild cooperatively breeding male banded mongooses.Scientific reports · 2025Article
- Convergent rates of protein evolution identify novel targets of sexual selection in primates.Evolution; international journal of organic evolution · 2024Article
- Comparative analysis of sperm motility in liquid and seminal coagulum portions between Bornean orangutan (Pongo pygmaeus) and chimpanzee (Pan troglodytes).Primates; journal of primatology · 2021Article
- Article
- Deletion of a Seminal Gene Cluster Reinforces a Crucial Role of SVS2 in Male Fertility.International journal of molecular sciences · 2019Article
- Quantitative evolutionary proteomics of seminal fluid from primates with different mating systems.BMC genomics · 2018Article
- Copulatory plugs inhibit the reproductive success of rival males.Journal of evolutionary biology · 2016Article
- From molecules to mating: Rapid evolution and biochemical studies of reproductive proteins.Journal of proteomics · 2016Review
- Article
- Rates of evolution of hominoid seminal proteins are correlated with function and expression, rather than mating system.Journal of molecular evolution · 2014Article
- Reproduction and immunity-driven natural selection in the human WFDC locus.Molecular biology and evolution · 2013Article
- The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility.Fertility and sterility · 2013Review
- Identification and function of proteolysis regulators in seminal fluid.Molecular reproduction and development · 2013Review
- Sequence diversity of Pan troglodytes subspecies and the impact of WFDC6 selective constraints in reproductive immunity.Genome biology and evolution · 2013Article
- Genetic disruption of the copulatory plug in mice leads to severely reduced fertility.PLoS genetics · 2013Article
- Interacting proteins on human spermatozoa: adaptive evolution of the binding of semenogelin I to EPPIN.PloS one · 2013Article
- Article
- Birth-and-death of KLK3 and KLK2 in primates: evolution driven by reproductive biology.Genome biology and evolution · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The hominoid primates (apes and humans) exhibit remarkable diversity in their social and sexual behavioral systems. This is reflected in many ways in their anatomy and physiology. For example, the testes and seminal vesicles are relatively large in species with high sperm competition like the chimpanzee and small in species with low or no sperm competition like the gorilla. Additionally, the chimpanzee is the only hominoid primate known to produce a firm copulatory plug, which presumably functions in sperm competition by blocking insemination of subsequent males. Here we examine the molecular evolution of the semenogelin genes (SEMG1 and SEMG2), which code for the predominant structural proteins in human semen. High molecular weight complexes of these proteins are responsible for the viscous gelatinous consistency of human semen; their rodent homologs are responsible for the formation of a firm copulatory plug. Chimpanzees have an expanded SEMG1 gene caused by duplications of tandem repeats, each encoding 60 amino acids, resulting in a protein nearly twice as long as that of humans. In contrast, at both SEMG1 and SEMG2 we observed several gorilla haplotypes that contain at least one premature stop codon. We suggest that these structural changes in the semenogelin proteins that have arisen since the human-chimpanzee-gorilla split may be responsible for the physiological differences between these species ejaculated semen that correlate with their sociosexual behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.