ArticleOncogene2003
Genetic interactions between Pten and p53 in radiation-induced lymphoma development.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Inhibition of PRL2 Upregulates PTEN and Attenuates Tumor Growth in Tp53-deficient Sarcoma and Lymphoma Mouse Models.Cancer research communications · 2024Article
- World Trade Center dust exposure promotes cancer in PTEN-deficient mouse prostates.Cancer research communications · 2022Article
- Nuclear PTEN and p53 suppress stress-induced liver cancer through distinct mechanisms.Biochemical and biophysical research communications · 2021Article
- Article
- Mouse models for radiation-induced cancers.Mutagenesis · 2016Review
- Article
- Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing.Cell · 2014Article
- Mouse models for efficacy testing of agents against radiation carcinogenesis—a literature review.International journal of environmental research and public health · 2012Review
- Article
- Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development.Molecular cancer research : MCR · 2012Article
- Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53.PloS one · 2012Article
- Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibility.PloS one · 2012Article
- PTEN loss in the continuum of common cancers, rare syndromes and mouse models.Nature reviews. Cancer · 2011Review
- Cis lethal genetic interactions attenuate and alter p53 tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Inactivation of p53 and Pten promotes invasive bladder cancer.Genes & development · 2009Article
- PTEN regulation by Akt-EGR1-ARF-PTEN axis.The EMBO journal · 2009Article
- Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer.Differentiation; research in biological diversity · 2009Article
- FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.Science (New York, N.Y.) · 2008Article
- Multi-step lymphomagenesis deduced from DNA changes in thymic lymphomas and atrophic thymuses at various times after gamma-irradiation.Oncogene · 2007Article
- Radiation carcinogenesis in mouse thymic lymphomas.Cancer science · 2006Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Genetic analysis of radiation-induced lymphomas from p53 heterozygous or null mice has revealed a high frequency of genetic alterations on mouse chromosome 19. Detailed microsatellite analysis of chromosome 19 deletions identified three independent regions of loss of heterozygosity, one of which was refined to a 0.3 Mb interval that contained the Pten tumor suppressor gene. More than 50% of radiation-induced tumors from p53+/- and p53-/- mice showed heterozygous loss of one Pten allele. In most cases, the remaining allele was wild type and expressed, suggesting that Pten is a haploinsufficient tumor suppressor gene for mouse lymphoma development. This conclusion was supported by the detection of specific intragenic deletions in Pten in tumors that retained one wild-type allele. Pten heterozygous mice were just as sensitive as p53+/- mice to induction of tumors by radiation, and surprisingly, the double p53+/-Pten+/-mice were equivalent to p53 null mice in radiation sensitivity. Despite the fact that Pten appears to be a haploinsufficient tumor suppressor gene, most tumors from both the single and double heterozygous mice had lost the remaining wild-type allele. The mechanism of loss in all cases involved the complete chromosome, suggesting that it is driven by other tumor suppressor genes on this chromosome. This sensitized screen therefore identified complementary roles for Pten and p53 pathways in suppression of tumor development induced by radiation exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.