ArticleNucleic acids research2003
Genome-wide analysis of gene expression regulated by the HAT cofactor Trrap in conditional knockout cells.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Stiffness assisted cell-matrix remodeling trigger 3D mechanotransduction regulatory programs.Biomaterials · 2024Article
- The TRRAP transcription cofactor represses interferon-stimulated genes in colorectal cancer cells.eLife · 2022Article
- The histone acetyltransferase component TRRAP is targeted for destruction during the cell cycle.Oncogene · 2014Article
- Tissue-specific inactivation of HAT cofactor TRRAP reveals its essential role in B cells.Cell cycle (Georgetown, Tex.) · 2014Article
- Domains of Tra1 important for activator recruitment and transcription coactivator functions of SAGA and NuA4 complexes.Molecular and cellular biology · 2011Article
- Dual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V(D)J recombination and T-cell development.Molecular and cellular biology · 2010Article
- Orchestration of chromatin-based processes: mind the TRRAP.Oncogene · 2007Review
- Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells.BMC genomics · 2007Article
- Gene expression profiling of bovine in vitro adipogenesis using a cDNA microarray.Functional & integrative genomics · 2006Article
- The transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repair.Molecular and cellular biology · 2006Article
- HAT cofactor Trrap regulates the mitotic checkpoint by modulation of Mad1 and Mad2 expression.The EMBO journal · 2004Article
- Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2.Nucleus (Austin, Tex.)Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transactivation/transformation-domain associated protein (TRRAP) is a component of several multi-protein HAT complexes implicated in both transcriptional regulation and DNA repair. We recently identified Trrap, the murine ortholog of TRRAP, as an essential protein implicated in mitotic progression control, although its target genes are not known. In the present study, we analyzed the expression profiles of Trrap-responsive genes, using cDNA microarray in mitotic cells. From a panel of 17 664 transcript elements, we found that loss of Trrap leads to expression alteration of a large fraction of genes at mitotic stage. Functional classification of these genes indicates that Trrap influences a variety of cellular processes including cell cycle progression, cytoskeleton and cell adhesion, protein turnover, metabolism and signal transduction. The majority (71%) of differentially expressed genes was down-regulated in Trrap- deficient cells, whereas the rest were up-regulated, suggesting that Trrap may also play a role in transcriptional silencing. ChIP analysis revealed that Trrap might regulate gene expression by participating in acetylation of histone H4 and/or H3 depending on target genes and cell cycle stage. Our study indicates that Trrap regulates the expression of a wide range of genes in both quiescence and mitotic stages. Removal of the Trrap protein is associated with both increased and decreased gene expression.
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Registered trials
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