ArticleNucleic acids research2003
Computational identification of the Spo0A-phosphate regulon that is essential for the cellular differentiation and development in Gram-positive spore-forming bacteria.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- A single DNA methylation site regulates cell fate during Clostridioides difficile sporulation.PLoS pathogens · 2026Article
- Identification of sporulation genes in Bacillus anthracis highlights similarities and significant differences with Bacillus subtilis.PLoS biology · 2025Article
- Novel modulators controlling entry into sporulation in Bacillus subtilis.Journal of bacteriology · 2013Article
- Article
- An A257V mutation in the bacillus subtilis response regulator Spo0A prevents regulated expression of promoters with low-consensus binding sites.Journal of bacteriology · 2009Article
- The cis-regulatory map of Shewanella genomes.Nucleic acids research · 2008Article
- Comparative genomic reconstruction of transcriptional regulatory networks in bacteria.Chemical reviews · 2007Review
- Spo0A, the key transcriptional regulator for entrance into sporulation, is an inhibitor of DNA replication.The EMBO journal · 2006Article
- More robust detection of motifs in coexpressed genes by using phylogenetic information.BMC bioinformatics · 2006Article
- Molecular basis for the exploitation of spore formation as survival mechanism by virulent phage phi29.The EMBO journal · 2005Article
- Characterization of sporulation histidine kinases of Bacillus anthracis.Journal of bacteriology · 2005Article
- Comparative genomics analysis of NtcA regulons in cyanobacteria: regulation of nitrogen assimilation and its coupling to photosynthesis.Nucleic acids research · 2005Article
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3 authors at 1 institution in 1 country.
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Abstract
Spo0A-phosphate is essential for the initiation of cellular differentiation and developmental processes in Gram-positive spore-forming bacteria. Here we combined comparative genomics with analyses of microarray expression profiles to identify the Spo0A-phosphate regulon in Bacillus subtilis. The consensus Spo0A-phosphate DNA-binding motif identified from the training set based on different computational algorithms is an 8 bp sequence, TTGTCGAA. The same motif was identified by aligning the upstream regulatory sequences of spo0A-dependent genes obtained from the expression profile of Sad67 (a constitutively active form of Spo0A) and their orthologs. After the transcription units (TUs) having putative Spo0A-phosphate binding sites were obtained, conservation of regulons among the genomes of B.subtilis, Bacillus halodurans and Bacillus anthracis, and expression profiles were employed to identify the most confident predictions. Besides genes already known to be directly under the control of Spo0A-phosphate, 276 novel members (organized in 109 TUs) of the Spo0A-phosphate regulon in B.subtilis are predicted in this study. The sensitivity and specificity of our predictions are estimated based on known sites and combinations of different types of evidence. Further characterization of the novel candidates will provide information towards understanding the role of Spo0A-phosphate in the sporulation process, as well as the entire genetic network governing cellular differentiation and developmental processes in B.subtilis.
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