ArticleNucleic acids research2003
Conservation of DNA curvature signals in regulatory regions of prokaryotic genes.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 87 citations in OpenAlex.
- Spatiotemporal Coupling of DNA Supercoiling and Genomic Sequence Organization-A Timing Chain for the Bacterial Growth Cycle?Biomolecules · 2022Review
- Dimerization site 2 of the bacterial DNA-binding protein H-NS is required for gene silencing and stiffened nucleoprotein filament formation.The Journal of biological chemistry · 2018Article
- Fitness Costs of Plasmids: a Limit to Plasmid Transmission.Microbiology spectrum · 2017Review
- The Potential Link between Thermal Resistance and Virulence inFrontiers in veterinary science · 2017Review
- RsmW, Pseudomonas aeruginosa small non-coding RsmA-binding RNA upregulated in biofilm versus planktonic growth conditions.BMC microbiology · 2016Article
- Mutations That Stimulate flhDC Expression in Escherichia coli K-12.Journal of bacteriology · 2015Article
- Chromosomal position shift of a regulatory gene alters the bacterial phenotype.Nucleic acids research · 2015Article
- Effect of promoter-upstream sequence on σ38-dependent stationary phase gene transcription.Journal of microbiology (Seoul, Korea) · 2015Article
- Upstream binding of idling RNA polymerase modulates transcription initiation from a nearby promoter.The Journal of biological chemistry · 2015Article
- Assessing diversity of DNA structure-related sequence features in prokaryotic genomes.DNA research : an international journal for rapid publication of reports on genes and genomes · 2014Article
- Binding of nucleoid-associated protein fis to DNA is regulated by DNA breathing dynamics.PLoS computational biology · 2013Article
- Genome-scale computational analysis of DNA curvature and repeats in Arabidopsis and rice uncovers plant-specific genomic properties.BMC genomics · 2011Article
- Rules extraction from neural networks applied to the prediction and recognition of prokaryotic promoters.Genetics and molecular biology · 2011Article
- Post-transcriptional global regulation by CsrA in bacteria.Cellular and molecular life sciences : CMLS · 2010Review
- Characterization of BNT2, an intrinsically curved DNA of Escherichia coli O157:H7.Biochemical and biophysical research communications · 2010Article
- A reexamination of information theory-based methods for DNA-binding site identification.BMC bioinformatics · 2009Article
- H-NS mediates the silencing of laterally acquired genes in bacteria.PLoS pathogens · 2006Article
- DNA bending in the replication zone of the C3 DNA puff amplicon of Rhynchosciara americana (Diptera: Sciaridae).Molecular biology reports · 2006Article
- The distinctive signatures of promoter regions and operon junctions across prokaryotes.Nucleic acids research · 2006Article
- Involvement of DNA curvature in intergenic regions of prokaryotes.Nucleic acids research · 2006Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA curvature plays a well-characterized role in many transcriptional regulation mechanisms. We present evidence for the conservation of curvature signals in putative regulatory regions of several archaeal and eubacterial genomes. Genes with highly curved upstream regions were identified in orthologous groups, based on the annotations of the Cluster of Orthologous Groups of proteins (COG) database. COGs possessing a significant number of genes with curvature signals were analyzed, and conserved properties were found in several cases. Curvature signals related to regulatory sites, previously described in single organisms, were located in a broad spectrum of bacterial genomes. Global regulatory proteins, such as HU, IHF and FIS, known to bind to curved DNA and to be autoregulated, were found to present conserved DNA curvature signals in their regulatory regions, emphasizing the fact that structural parameters of the DNA molecule are conserved elements in the process of transcriptional regulation of some systems. It is currently an open question whether these diverse systems are part of an integrated global regulatory response in different microorganisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.