ArticleNucleic acids research2003
Dynamic methylation of histone H3 at lysine 4 in transcriptional regulation by the androgen receptor.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Androgen receptor-mediated downregulation of microRNA-221 and -222 in castration-resistant prostate cancer.PloS one · 2017Article
- In-Depth Characterization and Validation of Human Urine Metabolomes Reveal Novel Metabolic Signatures of Lower Urinary Tract Symptoms.Scientific reports · 2016Article
- BAY 1024767 blocks androgen receptor mutants found in castration-resistant prostate cancer patients.Oncotarget · 2016Article
- Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells.Molecular and cellular biology · 2011Article
- Dynamic interplay between histone H3 modifications and protein interpreters: emerging evidence for a "histone language".Chembiochem : a European journal of chemical biology · 2011Review
- Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal transducer and activator of transcription 1 (STAT1)-activated transcription of the interferon regulatory factor 1 gene (IRF1).Epigenetics & chromatin · 2010Article
- Protein arginine methyltransferase 6 regulates multiple aspects of gene expression.Nucleic acids research · 2010Article
- Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM.Molecular and cellular biology · 2010Article
- Influence of nucleophosmin/B23 on DNA binding and transcriptional activity of the androgen receptor in prostate cancer cell.Oncogene · 2008Article
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- Epigenetic regulation of tumor necrosis factor alpha.Molecular and cellular biology · 2007Article
- Genome-wide dynamics of SAPHIRE, an essential complex for gene activation and chromatin boundaries.Molecular and cellular biology · 2007Article
- Article
- Androgen receptor and prostate cancer.Prostate cancer and prostatic diseases · 2007Review
- Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells.Molecular and cellular biology · 2006Article
- Cell-type-specific epigenetic marking of the IL2 gene at a distal cis-regulatory region in competent, nontranscribing T-cells.Nucleic acids research · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The methylation of histone H3 correlates with either gene expression or silencing depending on the residues modified. Methylated lysine 4 (H3-K4) is associated with transcription at active gene loci. Furthermore, it was reported that trimethylated but not dimethylated H3-K4 is exclusively associated with active chromatin in Saccharomyces cerevisiae. In the present study, we investigated the H3-K4 methylation at the human prostate specific antigen (PSA) locus following gene activation and repression via androgen receptor (AR). We show that ligand-induced, AR-mediated transcription was accompanied by rapid decreases in di- and trimethylated H3-K4 at the PSA enhancer and promoter. Moreover, the observed decreases in H3-K4 methylation were reversed when AR was inhibited by a specific AR antagonist, bicalutamide. In contrast to the decreases in methylation at the 5' transcriptional control regions of the PSA gene, H3-K4 methylation in the coding region steadily increased after a lag period of approximately 4 h. The results suggest a novel role of methylated H3-K4 in transcriptional regulation.
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