ArticleJournal of medical genetics2003
Identification of recurrent regions of chromosome loss and gain in vestibular schwannomas using comparative genomic hybridisation.
Article in Journal of medical genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Contemporary Molecular Biology of Sporadic Vestibular Schwannomas: A Systematic Review and Clinical Implications.The journal of international advanced otology · 2018Pooled it
- Clinical and inflammatory factors associated with the extent of resection in primary, sporadic vestibular schwannomas: A retrospective study.Acta neuropathologica communications · 2025Article
- Benign Spinal Tumors.Advances in experimental medicine and biology · 2023Article
- The Diagnostic Accuracy of Pure-Tone Audiometry Screening Protocols for Vestibular Schwannoma in Patients with Asymmetrical Hearing Loss-A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Review
- Vestibular Schwannoma: What We Know and Where We are Heading.Head and neck pathology · 2020Review
- Gamma Knife Radiosurgery does not alter the copy number aberration profile in sporadic vestibular schwannoma.Journal of neuro-oncology · 2020Article
- The molecular pathogenesis of schwannomatosis, a paradigm for the co-involvement of multiple tumour suppressor genes in tumorigenesis.Human genetics · 2017Review
- P14ARF deficiency and its correlation with overexpression of p53/MDM2 in sporadic vestibular schwannomas.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2015Article
- Evidence of polyclonality in neurofibromatosis type 2-associated multilobulated vestibular schwannomas.Neuro-oncology · 2015Article
- DNA copy gains of tumor-related genes in vestibular schwannoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2013Article
- Merlin, the NF2 gene product.Pathology oncology research : POR · 2013Review
- Microarray analysis of gene expression in vestibular schwannomas reveals SPP1/MET signaling pathway and androgen receptor deregulation.International journal of oncology · 2013Article
- Article
- Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients.Croatian medical journal · 2012Article
- The molecular biology of vestibular schwannomas and its association with hearing loss: a review.Genetics research international · 2012Article
- Analysis of cytogenetic aberrations in sporadic vestibular schwannoma by comparative genomic hybridization.Journal of neuro-oncology · 2011Article
- Article
- Neurofibromatosis type 2 (NF2): a clinical and molecular review.Orphanet journal of rare diseases · 2009Review
- Cytogenetic characterizations of central nervous system tumors: the first comprehensive report from a single institution in Korea.Journal of Korean medical science · 2009Article
- Role of NF2 haploinsufficiency in NF2-associated polyneuropathy.Brain pathology (Zurich, Switzerland) · 2007Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSchwannomas are benign tumours of the nervous system that are usually sporadic but also occur in the inherited disorder neurofibromatosis type 2 (NF2). The NF2 gene is a tumour suppressor on chromosome 22. Loss of expression of the NF2 protein product, merlin, is universal in both sporadic and NF2 related schwannomas. The GTPase signalling molecules RhoA and Rac1 regulate merlin function, but to date only mutation in the NF2 gene has been identified as a causal event in schwannoma formation.
methodsComparative genomic hybridisation (CGH) was used to screen 76 vestibular schwannomas from 76 patients (66 sporadic and 10 NF2 related) to identify other chromosome regions that may harbour genes involved in the tumorigenesis.
resultsThe most common change was loss on chromosome 22, which was more frequent in sporadic than in NF2 related tumours. Importantly, eight tumours (10%) showed gain of copy number on chromosome 9q34. Each of the two NF2 patients who had received stereotactic radiotherapy had non-chromosome 22 changes, whereas only one of eight non-irradiated NF2 patients had any chromosome changes. Three tumours had gain on 17q, which has also been reported in malignant peripheral nerve sheath tumours that are associated with neurofibromatosis type 1. Other sites that were identified in three or fewer tumours were regions on chromosomes 10, 11, 13, 16, 19, 20, X, and Y.
conclusionsThese findings should be verified using techniques that can detect smaller genetic changes, such as microarray-CGH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.