ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Tlx controls proliferation and patterning of lateral telencephalic progenitor domains.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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Who cites it
57 citing papers in PubMed, 91 citations in OpenAlex.
- Indirect neurogenesis in space and time.Nature reviews. Neuroscience · 2024Review
- Patterning ganglionic eminences in developing human brain organoids using a morphogen-gradient-inducing device.Cell reports methods · 2024Article
- Selective dopamine D2 receptor deletion from Nkx6.2 expressing cells causes impaired cognitive, motivation and anxiety phenotypes in mice.Scientific reports · 2023Article
- Human MiniPromoters for ocular-rAAV expression in ON bipolar, cone, corneal, endothelial, Müller glial, and PAX6 cells.Gene therapy · 2021Article
- Development of the mouse anterior amygdalar radial unit marked by Lhx9-expression.Brain structure & function · 2021Article
- Gene regulatory networks controlling differentiation, survival, and diversification of hypothalamic Lhx6-expressing GABAergic neurons.Communications biology · 2021Article
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- Cortical interneuron specification: the juncture of genes, time and geometry.Current opinion in neurobiology · 2017Review
- CONSERVED AND EXAPTED FUNCTIONS OF NUCLEAR RECEPTORS IN ANIMAL DEVELOPMENT.Nuclear receptor research · 2017Article
- Developmental interneuron subtype deficits after targeted loss of Arx.BMC neuroscience · 2016Article
- The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model.Nature communications · 2016Article
- Analysis of Gene Expression Profiles in the Human Brain Stem, Cerebellum and Cerebral Cortex.PloS one · 2016Article
- Combined serial analysis of gene expression and transcription factor binding site prediction identifies novel-candidate-target genes of Nr2e1 in neocortex development.BMC genomics · 2015Article
- TLX: A master regulator for neural stem cell maintenance and neurogenesis.Biochimica et biophysica acta · 2015Review
- Cerebral Cortex Expression of Gli3 Is Required for Normal Development of the Lateral Olfactory Tract.PloS one · 2015Article
- Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor.Frontiers in cellular neuroscience · 2015Article
- Derivation and isolation of NKX2.1-positive basal forebrain progenitors from human embryonic stem cells.Stem cells and development · 2013Article
- MicroRNA let-7d regulates the TLX/microRNA-9 cascade to control neural cell fate and neurogenesis.Scientific reports · 2013Article
- Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons.Stem cells and development · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We showed previously that the orphan nuclear receptor Tlx is required for the correct establishment of the pallio-subpallial boundary. Loss of Tlx results in a dorsal expansion of ventral markers (e.g., the homeodomain protein GSH2) into the ventralmost pallial region, i.e., the ventral pallium. We also observed a disproportionate reduction in the size of the Tlx mutant lateral ganglionic eminence (LGE) from embryonic day 14.5 onward. Here we show that this reduction is caused, at least in large part, by a proliferation defect. Interestingly, in Tlx mutants, the LGE derivatives are differentially affected. Although the development of the Tlx mutant striatum is compromised, an apparently normal number of olfactory bulb interneurons are observed. Consistent with this observation, we found that Tlx is required for the normal establishment of the ventral LGE that gives rise to striatal projection neurons. This domain is reduced by the dorsal and ventral expansion of molecular markers normally confined to progenitor domains flanking the ventral LGE. Finally, we investigated possible genetic interactions between Gsh2 and Tlx in lateral telencephalic development. Our results show that, although Gsh2 and Tlx have additive effects on striatal development, they differentially regulate the establishment of ventral pallial identity.
Indexed as
Identifiers
14627641PMC6740920W1825846406What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.