ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Selective reactions of cutaneous and muscle afferent neurons to peripheral nerve transection in rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 92 citations in OpenAlex.
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- Satellite Glial Cells Give Rise to Nociceptive Sensory Neurons.Stem cell reviews and reports · 2021Article
- Prior perineural or neonatal treatment with capsaicin does not alter the development of spinal microgliosis induced by peripheral nerve injury.Cell and tissue research · 2021Article
- Inhibition of Muscular Nociceptive Afferents via the Activation of Cutaneous Nociceptors in a Rat Model of Inflammatory Muscle Pain.Neuroscience bulletin · 2020Article
- Rethinking the causes of pain in herpes zoster and postherpetic neuralgia: the ectopic pacemaker hypothesis.Pain reports · 2018Review
- NaJournal of neurophysiology · 2018Article
- Single-cell RNA-seq reveals distinct injury responses in different types of DRG sensory neurons.Scientific reports · 2016Article
- Effects of peripheral nerve injury on parvalbumin expression in adult rat dorsal root ganglion neurons.BMC neuroscience · 2015Article
- Functional expression of α7-nicotinic acetylcholine receptors by muscle afferent neurons.Journal of neurophysiology · 2014Article
- Identification of specific sensory neuron populations for study of expressed ion channels.Journal of visualized experiments : JoVE · 2013Article
- Advances in peripheral nerve regeneration.Nature reviews. Neurology · 2013Review
- Identification of CaV channel types expressed in muscle afferent neurons.Journal of neurophysiology · 2013Article
- Tetrodotoxin-resistant voltage-dependent sodium channels in identified muscle afferent neurons.Journal of neurophysiology · 2012Article
- Mitochondrial involvement in sensory neuronal cell death and survival.Experimental brain research · 2012Article
- Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF.Journal of neurochemistry · 2012Article
- Recent progress in histochemistry and cell biology.Histochemistry and cell biology · 2012Review
- Sural nerve involvement in experimental hypertension: morphology and morphometry in male and female normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR).BMC neuroscience · 2012Article
- Phenotype of distinct primary sensory afferent subpopulations and caspase-3 expression following axotomy.Histochemistry and cell biology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine whether peripheral nerve injury has similar effects on all functional types of afferent neuron, we retrogradely labeled populations of neurons projecting to skin and to muscle with FluoroGold and lesioned various peripheral nerves in the rat. Labeled neurons were counted after different periods and related to immunohistochemically identified ectopic terminals and satellite cells in lumbar dorsal root ganglia. After 10 weeks, 30% of cutaneous afferent somata labeled from transected sural nerves had disappeared but, if all other branches of the sciatic nerve had also been cut, 60% of cutaneous neurons were lost. Small-diameter sural neurons preferentially disappeared. In contrast, the number of muscle afferent somata was not affected by transection of various nerves. p75 was downregulated in axotomized cutaneous neurons but in not axotomized muscle neurons. Conversely, p75 was upregulated in satellite cells around cutaneous but not muscle neurons. Consistent with this, perineuronal rings containing tyrosine hydroxylase, calcitonin gene-related peptide, galanin, or synaptophysin were formed preferentially around cutaneous neurons. Selective lesions of predominantly cutaneous nerves triggered the formation of rings, but none were detected after selective lesions of muscle nerves. We conclude that cutaneous neurons are both more vulnerable and more associated with ectopic nerve terminals than muscle neurons in dorsal root ganglia after transection and ligation of peripheral nerves.
Indexed as
Identifiers
14627640PMC6740909W1890566332What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.