ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Resonant synchronization in heterogeneous networks of inhibitory neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed.
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- Interneuronal network model of theta-nested fast oscillations predicts differential effects of heterogeneity, gap junctions and short term depression for hyperpolarizing versus shunting inhibition.PLoS computational biology · 2022Article
- Collective Dynamics of Neural Networks With Sleep-Related Biological Drives in Drosophila.Frontiers in computational neuroscience · 2021Article
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- Synchronization of Independent Neural Ensembles in Human EEG during Choice Tasks.Behavioral sciences (Basel, Switzerland) · 2019Article
- Phase response theory explains cluster formation in sparsely but strongly connected inhibitory neural networks and effects of jitter due to sparse connectivity.Journal of neurophysiology · 2019Article
- Hippocampal Ripple Oscillations and Inhibition-First Network Models: Frequency Dynamics and Response to GABA Modulators.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Spiking resonances in models with the same slow resonant and fast amplifying currents but different subthreshold dynamic properties.Journal of computational neuroscience · 2017Article
- Identifying Anatomical Origins of Coexisting Oscillations in the Cortical Microcircuit.PLoS computational biology · 2016Article
- Regulation of Irregular Neuronal Firing by Autaptic Transmission.Scientific reports · 2016Article
- Experimentally Verified Parameter Sets for Modelling Heterogeneous Neocortical Pyramidal-Cell Populations.PLoS computational biology · 2015Article
- Interactions between Inhibitory Interneurons and Excitatory Associational Circuitry in Determining Spatio-Temporal Dynamics of Hippocampal Dentate Granule Cells: A Large-Scale Computational Study.Frontiers in systems neuroscience · 2015Article
- Fluctuations in oscillation frequency control spike timing and coordinate neural networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Population dynamics of the modified theta model: macroscopic phase reduction and bifurcation analysis link microscopic neuronal interactions to macroscopic gamma oscillation.Journal of the Royal Society, Interface · 2014Article
- A supercritical density of Na(+) channels ensures fast signaling in GABAergic interneuron axons.Nature neuroscience · 2014Article
- Parametric Anatomical Modeling: a method for modeling the anatomical layout of neurons and their projections.Frontiers in neuroanatomy · 2014Article
- A spiking network model of cerebellar Purkinje cells and molecular layer interneurons exhibiting irregular firing.Frontiers in computational neuroscience · 2014Article
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2 authors.
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Abstract
Brain rhythms arise through the synchronization of neurons and their entrainment in a regular firing pattern. In this process, networks of reciprocally connected inhibitory neurons are often involved, but what mechanism determines the oscillation frequency is not completely understood. Analytical studies predict that the emerging frequency band is primarily constrained by the decay rate of the unitary IPSC. We observed a new phenomenon of resonant synchronization in computer-simulated networks of inhibitory neurons in which the synaptic current has a delayed onset, reflecting finite spike propagation and synaptic transmission times. At the resonant level of network excitation, all neurons fire synchronously and rhythmically with a period approximately four times the mean delay of the onset of the inhibitory synaptic current. The amplitude and decay time constant of the synaptic current have relatively minor effects on the emerging frequency band. By varying the axonal delay of the inhibitory connections, networks with a realistic synaptic kinetics can be tuned to frequencies from 40 to >200 Hz. This resonance phenomenon arises in heterogeneous networks with, on average, as few as five connections per neuron. We conclude that the delay of the synaptic current is the primary parameter controlling the oscillation frequency of inhibitory networks and propose that delay-induced synchronization is a mechanism for fast brain rhythms that depend on intact inhibitory synaptic transmission.
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