ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Optical measurements of presynaptic release in mutant zebrafish lacking postsynaptic receptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish.Communications biology · 2021Article
- αM-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish.Toxins · 2020Article
- Expressing acetylcholine receptors after innervation suppresses spontaneous vesicle release and causes muscle fatigue.Scientific reports · 2017Article
- Fatigue in Rapsyn-Deficient Zebrafish Reflects Defective Transmitter Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Nonequivalent release sites govern synaptic depression.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- Paired patch clamp recordings from motor-neuron and target skeletal muscle in zebrafish.Journal of visualized experiments : JoVE · 2010Article
- Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- A modified acetylcholine receptor delta-subunit enables a null mutant to survive beyond sexual maturation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Function of neuromuscular synapses in the zebrafish choline-acetyltransferase mutant bajan.Journal of neurophysiology · 2008Article
- Essential roles of the acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning.Development (Cambridge, England) · 2008Article
- A null mutation for the alpha3 nicotinic acetylcholine (ACh) receptor gene abolishes fast synaptic activity in sympathetic ganglia and reveals that ACh output from developing preganglionic terminals is regulated in an activity-dependent retrograde manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Acetylcholine receptors direct rapsyn clusters to the neuromuscular synapse in zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Differentiation of presynaptic nerve terminals is mediated, in part, through contact with the appropriate postsynaptic target cell. In particular, studies using dissociated nerve and muscle derived from Xenopus embryos have indicated that the properties of transmitter release from motor neurons are altered after contact with skeletal muscle. This maturation of presynaptic function has further been linked to retrograde signaling from muscle that involves activation of postsynaptic ACh receptors. Using FM1-43 optical determinants of exocytosis, we now compare calcium-mediated exocytosis at neuromuscular junctions of wild-type zebrafish to mutant fish lacking postsynaptic ACh receptors. In response to either high-potassium depolarization or direct electrical stimulation, we observed no differences in the rate or extent of FM1-43 destaining. These data indicate that the acquisition of stimulus-evoked exocytosis at early developmental stages occurs independent of both postsynaptic receptor and synaptic responses in zebrafish.
Indexed as
Identifiers
14627630PMC6740929W1800024412What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.