ArticleDigestive diseases and sciences2003
Acute acalculous cholecystitis associated with systemic sepsis and visceral arterial hypoperfusion: a case series and review of pathophysiology.
Article in Digestive diseases and sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- New diagnostic criteria and severity assessment of acute cholecystitis in revised Tokyo Guidelines.Journal of hepato-biliary-pancreatic sciences · 2012Guideline
- When Feeding Tubes Cause Biliary Disease: A Case of Acalculous Cholecystitis Due to Gastrostomy Tube Obstruction.Cureus · 2026Article
- Article
- Case Report: Cholecystitis and gastric perforation caused by a fishbone and treated by laparoscopic surgery.Frontiers in medicine · 2025Article
- Disentangling the phenotypic patterns of hypertension and chronic hypotension.Journal of biomedical informatics · 2024Article
- Review
- Metabolic dysfunction-associated gallstone disease: expecting more from critical care manifestations.Internal and emergency medicine · 2023Review
- Acute acalculous cholecystitis and cardiovascular disease, which came first? After two hundred years still the classic chicken and eggs debate: A review of literature.Annals of medicine and surgery (2012) · 2022Review
- Acalculous Cholecystitis in a Young Adult with Scrub Typhus: A Case Report and Epidemiology of Scrub Typhus in the Maldives.Tropical medicine and infectious disease · 2021Article
- Acute acalculous cholecystitis due to infectious causes.World journal of clinical cases · 2021Review
- Effects of Serum Metabolites on the Pancreatic Transcriptome in Acute Acalculous Cholecystitis.Gastroenterology research and practice · 2021Article
- Prognostic Significance of Ultrasound Findings of Acute Acalculous Cholecystitis for Elderly Long-Term Bedridden Patients.Frontiers in medicine · 2021Article
- Compared With a Nasointestinal Route, Pre-operative Enteral NutritionFrontiers in medicine · 2021Article
- Hepatitis C Virus-Associated Acalculous Cholecystitis and Review of the Literature.Clinical medicine & research · 2020Review
- Systemic Lupus Erythematosus-associated Acute Acalculous Cholecystitis Successfully Treated by a Corticosteroid Combined with Azathioprine.Internal medicine (Tokyo, Japan) · 2019Article
- Article
- Critical Care Aspects of Gallstone Disease.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2019Article
- A Case Report of Acute Abdominal Pain From a Rare Infectious Etiology.Global pediatric health · 2018Article
- Acute acalculous cholecystitis caused by Hepatitis C: A rare case report.International journal of surgery case reports · 2016Article
- Acute acalculous cholecystitis and cardiovascular disease: a land of confusion.Journal of ultrasound · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute acalculous cholecystitis (AAC) is marked by a very high mortality rate but its relative rarity makes its features obscure to many physicians. This often contributes to a delayed diagnosis. In this study, we review one center's experience, examine the clinical features of the disorder, and describe the progression of pathological events that culminate in AAC. We performed a 10-year retrospective review of cases of AAC reported at our institution between 1988 and 1998. Fifteen cases of AAC were identified from this period, during which 5804 cardiovascular operations were performed. The mortality rate was 46.6%. Multiple organ failure was present in 12 of the 15 cases, and 9 of the patients were over 60 years of age. Prolonged hypotension occurred in 13 patients, and fever in all 15. Nine cases of gangrenous gallbladder occurred. Gram-negative septicemia was present in 12. Visceral arterial hypoperfusion was frequently evident at operation or necropsy. Thirteen patients showed clinical jaundice, a disproportionate elevation of the alkaline phosphatase, or both. Heart failure was found in 9 patients. Open cholecystectomy was most often the definitive intervention. Arterial hypoperfusion of the gut and or sepsis appear central to the pathogenesis of AAC in our series. Gallbladder inflammation and cholestasis result and bacterial invasion of the organ ensues, culminating in AAC, frequently with gangrene. A model of the pathogenesis of AAC is discussed.
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