ArticleCell stress & chaperones2003
Oxidative stress impairs intracellular events involved in antigen processing and presentation to T cells.
Article in Cell stress & chaperones, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
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- Prolonged exposure to leisure screen time notably accelerates biological aging: Evidence from observational studies and genetic associations.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Observational
- Restorative Effects of Synbiotics on Colonic Ultrastructure and Oxidative Stress in Dogs with Chronic Enteropathy.Antioxidants (Basel, Switzerland) · 2025Article
- Prevention of tuberculosis in cynomolgus macaques by an attenuated Mycobacterium tuberculosis vaccine candidate.Nature communications · 2025Article
- Measurement of serum 1,5-AG provides insights for diabetes management and the anti-viral immune response.Cellular and molecular life sciences : CMLS · 2025Article
- Tumors Established in a Defective Immune Environment Reprogram the Oncogenic Signaling Pathways to Escalate Tumor Antigenicity.Biomedicines · 2024Article
- Potential ameliorative role of Spirulina platensis in powdered or extract forms against cyclic heat stress in broiler chickens.Environmental science and pollution research international · 2022Article
- Synergistic effect of Spirulina platensis and selenium nanoparticles on growth performance, serum metabolites, immune responses, and antioxidant capacity of heat-stressed broiler chickens.Biological trace element research · 2022Article
- Oxidative Stress Compromises Lymphocyte Function in Neonatal Dairy Calves.Antioxidants (Basel, Switzerland) · 2021Article
- Review
- Differential Carbonyl Stress Expression in the Intervertebral Disc between Singular- and Persistent-Mechanical Injuries.Nagoya Gakuin Daigaku ronshu. Igaku, kenko kagaku, supotsu kagakuhen · 2017Article
- Is immunosenescence influenced by our lifetime "dose" of exercise?Biogerontology · 2016Review
- CSF isoprostane levels are a biomarker of oxidative stress in multiple sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2014Article
- Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation.Journal of leukocyte biology · 2013Review
- Age-related carbonylation of fibrocartilage structural proteins drives tissue degenerative modification.Chemistry & biology · 2013Article
- Article
- Age-related oxidative stress compromises endosomal proteostasis.Cell reports · 2012Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For T cells to recognize foreign antigens, the latter must be processed into peptides and associated to major histocompatibility complex (MHC) class II molecules by antigen-presenting cells (APC). APCs frequently operate under stress conditions induced by tissue damage, antigens, or inflammatory reactions. We analyze the effects of oxidative stress on intracellular processing using APC B cell lines. Before being tested for APC function, B cells (IIA1.6) were exposed for 2 hours to hydrogen peroxide (H2O2), a treatment that impairs their capacity to stimulate specific T cell clones. Because paraformaldehyde-fixed H2O2-treated B cells can still present extracellular peptides to T cell clones, the intracellular events of processing were investigated. Purified lysosomes from H2O2-treated B cells show increased proteolytic activity and increased generation of antigenic peptides. In addition, H2O2 treatment targets antigens to compartments that express low levels of MHC II and proteins (H-2M, H-2O) required for peptide loading onto this molecule. Finally, we suggest that impairment of antigen processing by oxidative stress reduces the induction of a T cell's response because H2O2 decreases the activation of naive T lymphocytes by dendritic cells. Together, these data indicate that oxidative stress inhibits the capacity of APCs to process antigens and to initiate a primary T cell response. The role of such modifications on the outcome of the specific immune response is discussed.
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Registered trials
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