ArticleJournal of translational medicine2003
Polymorphism in clinical immunology - From HLA typing to immunogenetic profiling.
Article in Journal of translational medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed.
- Risk of drug-induced liver injury in multiple system atrophy patients treated with KM-819 is potentially associated with the HLA-DPB1*05:01:01:01 allele.The pharmacogenomics journal · 2026Trial
- Impact of mRNA COVID-19 vaccination on hematological parameters in patients maintained on clozapine: A retrospective study from Qatar.Exploratory research in clinical and social pharmacy · 2025Article
- Inflammation and Macrophage Loss Mark Increased Susceptibility in a Genetic Model of Acute Viral Infection-Induced Tissue Damage.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- LRMAHpan: a novel tool for multi-allelic HLA presentation prediction using Resnet-based and LSTM-based neural networks.Frontiers in immunology · 2024Article
- Genetic Association Studies ofDiagnostics (Basel, Switzerland) · 2023Article
- Genetic polymorphisms of IL6 gene -174G > C and -597G > A are associated with the risk of COVID-19 severity.International journal of immunogenetics · 2023Article
- Immunomodulation and immunotherapeutics of COVID-19.Clinical immunology (Orlando, Fla.) · 2021Review
- Association betweenGenes · 2021Article
- Microbiota and Ocular Diseases.Frontiers in cellular and infection microbiology · 2021Review
- Platelet-Rich Plasma Ameliorates Monosodium Iodoacetate-Induced Ankle Osteoarthritis in the Rat Model via Suppression of Inflammation and Oxidative Stress.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- HLA polymorphism and tapasin independence influence outcomes of HIV and dengue virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Quantification of Uncertainty in Peptide-MHC Binding Prediction Improves High-Affinity Peptide Selection for Therapeutic Design.Cell systems · 2019Article
- DeepLigand: accurate prediction of MHC class I ligands using peptide embedding.Bioinformatics (Oxford, England) · 2019Article
- Impact of inflammatory signaling on radiation biodosimetry: mouse model of inflammatory bowel disease.BMC genomics · 2019Article
- The microbiome and HLA-B27-associated acute anterior uveitis.Nature reviews. Rheumatology · 2018Review
- Human leukocyte antigen class 1 genotype distribution and analysis in persons with active tuberculosis and household contacts from Central Uganda.BMC infectious diseases · 2016Article
- sNebula, a network-based algorithm to predict binding between human leukocyte antigens and peptides.Scientific reports · 2016Article
- Relationship between HLA-DRB1 allele polymorphisms and familial aggregations of hepatocellular carcinoma.Current oncology (Toronto, Ont.) · 2016Article
- Pharmacogenetics of antiepileptic drugs: A brief review.The mental health clinician · 2016Review
- Complete haplotype phasing of the MHC and KIR loci with targeted HaploSeq.BMC genomics · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathology of humans, in contrast to that of inbred laboratory animals faces the challenge of diversity addressed in genetic terms as polymorphism. Thus, unsurprisingly, treatment modalities that successfully can be applied to carefully-selected pre-clinical models only sporadically succeed in the clinical arena. Indeed, pre-fabricated experimental models purposefully avoid the basic essence of human pathology: the uncontrollable complexity of disease heterogeneity and the intrinsic diversity of human beings. Far from pontificating on this obvious point, this review presents emerging evidence that the study of complex system such as the cytokine network is further complicated by inter-individual differences dictated by increasingly recognized polymorphisms. Polymorphism appears widespread among genes of the immune system possibly resulting from an evolutionary adaptation of the organism facing an ever evolving environment. We will refer to this high variability of immune-related genes as immune polymorphism. In this review we will briefly highlight the possible clinical relevance of immune polymorphism and suggest a change in the approach to the study of human pathology, from the targeted study of individual systems to a broader view of the organism as a whole through immunogenetic profiling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.