ArticlePLoS biology2003
Learning to control a brain-machine interface for reaching and grasping by primates.
Article in PLoS biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 579 papers.
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Who cites it
579 citing papers in PubMed, 1,775 citations in OpenAlex.
- Speech motor cortex enables BCI cursor control and click.Journal of neural engineering · 2025Trial
- Training with noninvasive brain-machine interface, tactile feedback, and locomotion to enhance neurological recovery in individuals with complete paraplegia: a randomized pilot study.Scientific reports · 2022Trial
- Speech-related dorsal motor cortex activity does not interfere with iBCI cursor control.Journal of neural engineering · 2020Trial
- Exploring representations of human grasping in neural, muscle and kinematic signals.Scientific reports · 2018Trial
- The Cybathlon BCI race: Successful longitudinal mutual learning with two tetraplegic users.PLoS biology · 2018Trial
- Trial
- High performance communication by people with paralysis using an intracortical brain-computer interface.eLife · 2017Trial
- Assistive algorithms influence neural representations in motor brain-computer interfaces.Nature communications · 2026Article
- Repeatable, low-drift recordings in behaving nonhuman primates using flexible microelectrodes.Nature communications · 2026Article
- Low-cost, open-source, full-stack software and Arduino-based hardware for control of commercially available animal behavior systems.Behavior research methods · 2026Article
- Minimally invasive implantation of scalable high-density cortical microelectrode arrays for multimodal neural decoding and stimulation.Nature biomedical engineering · 2026Article
- Intracortical brain-computer interface for navigation in virtual reality in macaque monkeys.Science advances · 2026Article
- Multi-area activity in mouse motor cortex associated with one- and two-handed oromanual dexterity.bioRxiv : the preprint server for biology · 2026Article
- A general model based on Riemannian manifold for stable decoding movement trajectory from ECoG signals.iScience · 2026Article
- An intracortical brain-machine interface based on macaque ventral premotor activity.Scientific reports · 2026Article
- Brain-computer interfaces as a causal probe for scientific inquiry.Trends in cognitive sciences · 2026Review
- Preconfigured neuronal firing sequences in human brain organoids.Nature neuroscience · 2026Article
- A wireless subdural-contained brain-computer interface with 65,536 electrodes and 1,024 channels.Nature electronics · 2025Article
- Long-term Intracortical Neural activity and Kinematics (LINK): An intracortical neural dataset for chronic brain-machine interfaces, neuroscience, and machine learning.Advances in neural information processing systems · 2025Article
- Neural trajectories improve motor precision.bioRxiv : the preprint server for biology · 2025Article
519 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reaching and grasping in primates depend on the coordination of neural activity in large frontoparietal ensembles. Here we demonstrate that primates can learn to reach and grasp virtual objects by controlling a robot arm through a closed-loop brain-machine interface (BMIc) that uses multiple mathematical models to extract several motor parameters (i.e., hand position, velocity, gripping force, and the EMGs of multiple arm muscles) from the electrical activity of frontoparietal neuronal ensembles. As single neurons typically contribute to the encoding of several motor parameters, we observed that high BMIc accuracy required recording from large neuronal ensembles. Continuous BMIc operation by monkeys led to significant improvements in both model predictions and behavioral performance. Using visual feedback, monkeys succeeded in producing robot reach-and-grasp movements even when their arms did not move. Learning to operate the BMIc was paralleled by functional reorganization in multiple cortical areas, suggesting that the dynamic properties of the BMIc were incorporated into motor and sensory cortical representations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.