ArticleThe Journal of cell biology2003
Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis.
Article in The Journal of cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
80 citing papers in PubMed, 148 citations in OpenAlex.
- ANXA1-Derived Peptide Increases Melanoma Cell Sensitivity to Vemurafenib by Downregulating EphA2.Journal of cellular and molecular medicine · 2026Article
- Cell death in glioblastoma and the central nervous system.Cellular oncology (Dordrecht, Netherlands) · 2025Review
- Apoptosis signaling is activated as a transient pulse in neurons.Cell death and differentiation · 2025Article
- Identification of a New Role of miR-199a-5p as Factor Implied in Neuronal Damage: Decreasing the Expression of Its Target X-Linked Anti-Apoptotic Protein (XIAP) After SCI.International journal of molecular sciences · 2024Article
- Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy.Cell death and differentiation · 2024Article
- Targeted Degradation of XIAP is Sufficient and Specific to Induce Apoptosis in MYCN-overexpressing High-risk Neuroblastoma.Cancer research communications · 2023Article
- Long Non-coding RNA Peg13 Alleviates Hypoxic-Ischemic Brain Damage in Neonatal Mice via miR-20a-5p/XIAP Axis.Neurochemical research · 2022Article
- p53 is required for nuclear but not mitochondrial DNA damage-induced degeneration.Cell death & disease · 2021Article
- FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function.Frontiers in cell and developmental biology · 2021Review
- Mitochondria as multifaceted regulators of cell death.Nature reviews. Molecular cell biology · 2020Review
- microRNA-192-5p is involved in nerve repair in rats with peripheral nerve injury by regulating XIAP.Cell cycle (Georgetown, Tex.) · 2020Article
- Scrap and Build for Functional Neural Circuits: Spatiotemporal Regulation of Dendrite Degeneration and Regeneration in Neural Development and Disease.Frontiers in cellular neuroscience · 2020Review
- Apoptotic cell death regulation in neurons.The FEBS journal · 2019Review
- Apoptosis versus axon pruning: Molecular intersection of two distinct pathways for axon degeneration.Neuroscience research · 2019Review
- Physiological functions of non-apoptotic caspase activity in the nervous system.Seminars in cell & developmental biology · 2018Review
- Dissociation of JNK Activation from Elevated Levels of Reactive Oxygen Species, Cytochrome c Release, and Cell Death in NGF-Deprived Sympathetic Neurons.Molecular neurobiology · 2018Article
- Doxorubicin-induced chronic dilated cardiomyopathy-the apoptosis hypothesis revisited.Journal of molecular medicine (Berlin, Germany) · 2017Review
- A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy.Frontiers in neuroscience · 2017Review
- Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival.PloS one · 2017Article
- Mature neurons dynamically restrict apoptosis via redundant premitochondrial brakes.The FEBS journal · 2016Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In sympathetic neurons, unlike most nonneuronal cells, growth factor withdrawal-induced apoptosis requires the development of competence in addition to cytochrome c release to activate caspases. Thus, although most nonneuronal cells die rapidly with cytosolic cytochrome c alone, sympathetic neurons are remarkably resistant unless they develop competence. We have identified endogenous X-linked inhibitor of apoptosis protein (XIAP) as the essential postcytochrome c regulator of caspase activation in these neurons. In contrast to wild-type neurons that are resistant to injection of cytochrome c, XIAP-deficient neurons died rapidly with cytosolic cytochrome c alone. Surprisingly, the release of endogenous Smac was not sufficient to overcome the XIAP resistance in sympathetic neurons. In contrast, the neuronal competence pathway permitted cytochrome c to activate caspases by inducing a marked reduction in XIAP levels in these neurons. Thus, the removal of XIAP inhibition appears both necessary and sufficient for cytochrome c to activate caspases in sympathetic neurons. These data identify a critical function of endogenous XIAP in regulating apoptosis in mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.