Trial reportEmergency medicine journal : EMJ2003
Randomised controlled trial of the onset of analgesic efficacy of dexketoprofen and diclofenac in lower limb injury.
Trial report in Emergency medicine journal : EMJ, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Systematic review of dexketoprofen in acute and chronic pain.BMC clinical pharmacology · 2008Pooled it
- Diclofenac sodium vs. dexketoprofen trometamol: selecting NSAIDs for managing postoperative inflammatory complications after third molar surgery-a randomized clinical trial.Head & face medicine · 2025Trial
- A multicentre, randomised, double-blind study comparing the efficacy and tolerability of intramuscular dexketoprofen versus diclofenac in the symptomatic treatment of acute low back pain.Clinical drug investigation · 2007Trial
- Development of Nanocochleates Containing Erlotinib HCl and Dexketoprofen Trometamol and Evaluation ofTurkish journal of pharmaceutical sciences · 2018Article
- Anaphylaxis after intravenous infusion of dexketoprofen trometamol.Turkish journal of emergency medicine · 2016Article
- Esophagitis due to dexketoprofen trometamol: a rare case report.Wiener klinische Wochenschrift · 2015Article
- Single-dose-dexketoprofen-induced acute kidney injury due to massive rhabdomyolysis.International urology and nephrology · 2012Article
- Efficacy and Tolerability of Intramuscular Dexketoprofen in Postoperative Pain Management following Hernia Repair Surgery.Anesthesiology research and practice · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the time of onset and difference in analgesic efficacy of oral dexketoprofen compared with oral diclofenac in patients with acute lower limb injury.
designA prospective, double blind, randomised controlled trial.
interventionsPatients who fitted the study criteria were given either 25 mg oral dexketoprofen trometamol or 50 mg sodium diclofenac immediately after triage; baseline and 15 minute pain scores were then recorded for one hour.
results122 patients were studied (diclofenac = 57 and dexketoprofen = 65). There were no significant differences in age, sex, type of injury, or baseline pain scores between the two groups. The differences in group mean pain scores between diclofenac and dexketoprofen at 15, 30, 45, and 60 minutes were; 0.53 (95% confidence intervals -0.03 to 1.09), 0.70 (0.16 to 1.24), 0.89 (0.32 to 1.47), and 0.83 (0.21 to 1.45). Odds ratios for a decrease in pain score of at least 1 from baseline (on the 11 point scale) when given dexketoprofen rather than diclofenac at 15, 30, 45, and 60 minutes were; 2.66 (1.19 to 5.98), 3.52 (1.60 to 7.73), 4.48 (1.72 to 11.65), and 5.54 (1.90 to 16.15). Corresponding odds ratios for a decrease in pain score of >/=2 were; 6.88 (1.48 to 32.0), 3.79 (1.59 to 9.01), 5.19 (2.29 to 11.78), and 5.87 (2.68 to 12.88).
conclusionsDexketoprofen trometamol is an effective and rapidly acting analgesic for the treatment of acute musculoskeletal injuries.
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Registered trials
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