ArticleJournal of feline medicine and surgery2003
Inflammation and changes in cytokine levels in neurological feline infectious peritonitis.
Article in Journal of feline medicine and surgery, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 73 citations in OpenAlex.
- The age-dependent neuroglial interaction with peripheral immune cells in coronavirus-induced neuroinflammation with a special emphasis on COVID-19.Biogerontology · 2025Review
- Evaluation of the course of improvement with molnupiravir treatment for feline infectious peritonitis.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- Comparison of Antiviral Immune Responses in Healthy Cats Induced by Two Immune Therapeutics.Pathogens (Basel, Switzerland) · 2024Article
- Article
- Article
- Therapeutic approaches to coronavirus infection according to "One Health" concept.Research in veterinary science · 2021Review
- Article
- Article
- Lifting the mask on neurological manifestations of COVID-19.Nature reviews. Neurology · 2020Review
- How SARS-Cov-2 can involve the central nervous system. A systematic analysis of literature of the department of human neurosciences of Sapienza University, Italy.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2020Review
- Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).Journal of medical virology · 2020Article
- SARS-CoV-2 Infection Leads to Neurological Dysfunction.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Article
- Neurological Damage by Coronaviruses: A Catastrophe in the Queue!Frontiers in immunology · 2020Review
- Coronavirus Infection of the Central Nervous System: Animal Models in the Time of COVID-19.Frontiers in veterinary science · 2020Article
- Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?Viruses · 2019Review
- A retrospective study of the neuropathology and diagnosis of naturally occurring feline infectious peritonitis.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2018Article
- Expression profiles of immune mediators in feline Coronavirus-infected cells and clinical samples of feline Coronavirus-positive cats.BMC veterinary research · 2017Article
- Glial response in the central nervous system of cats with feline infectious peritonitis.Journal of feline medicine and surgery · 2016Article
- Human coronaviruses: viral and cellular factors involved in neuroinvasiveness and neuropathogenesis.Virus research · 2014Review
- Neuroinvasive and neurotropic human respiratory coronaviruses: potential neurovirulent agents in humans.Advances in experimental medicine and biology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feline infectious peritonitis (FIP) is a progressive, fatal, predominantly Arthus-type immune-mediated disease that is triggered when cats are infected with a mutant enteric coronavirus. The disease presents variably with multiple organ failure, seizures, generalized effusion, or shock. Neurological FIP is clinically and pathologically more homogeneous than systemic 'wet' or 'dry' FIP; thus, comparison of cytokine profiles from cats with neurological FIP, wet FIP, and non-FIP neurological disease may provide insight into some baseline characteristics relating to the immunopathogenesis of neurological FIP. This study characterizes inflammation and changes in cytokines in the brain tissue of FIP-affected cats. Cellular infiltrates in cats with FIP included lymphocytes, plasma cells, neutrophils, macrophages, and eosinophils. IL-1 beta, IL-6, IL-12, IL-18, TNF-alpha, macrophage inhibitory protein (MIP)-1 alpha, and RANTES showed no upregulation in the brains of control cats, moderate upregulation in neurological FIP cats, and very high upregulation in generalized FIP cats. Transcription of IFN-gamma appeared upregulated in cats with systemic FIP and slightly downregulated in neurological FIP. In most cytokines tested, variance was extremely high in generalized FIP and much less in neurological FIP. Principal components analysis was performed in order to find the least number of 'components' that would summarize the cytokine profiles in cats with neurological FIP. A large component of the variance (91.7%) was accounted for by levels of IL-6, MIP-1 alpha, and RANTES. These findings provide new insight into the immunopathogenesis of FIP and suggest targets for immune therapy of this disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.