ArticleAAPS PharmSciTech2003
Preparation and characterization of novel coenzyme Q10 nanoparticles engineered from microemulsion precursors.
Article in AAPS PharmSciTech, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Physicochemical Properties, Antioxidant Capacity and Bioavailability of Whey Protein Concentrate-Based Coenzyme Q10 Nanoparticles.Antioxidants (Basel, Switzerland) · 2024Article
- An Overview on Topical Administration of Carotenoids and Coenzyme Q10 Loaded in Lipid Nanoparticles.Antioxidants (Basel, Switzerland) · 2021Review
- Innovative coenzyme QDrug delivery and translational research · 2020Article
- Effects of In Ovo Injection of Coenzyme Q10 on Hatchability, Subsequent Performance, and Immunity of Broiler Chickens.BioMed research international · 2019Article
- Stability of astaxanthin-loaded nanostructured lipid carriers as affected by pH, ionic strength, heat treatment, simulated gastric juice and freeze-thawing.Journal of food science and technology · 2017Article
- PLA micro- and nano-particles.Advanced drug delivery reviews · 2016Review
- Design and evaluation of multifunctional nanocarriers for selective delivery of coenzyme Q10 to mitochondria.Biomacromolecules · 2012Article
- A comparative evaluation of coenzyme Q10-loaded liposomes and solid lipid nanoparticles as dermal antioxidant carriers.International journal of nanomedicine · 2012Article
- Protective effects of nanoparticulate coenzyme Q10 and curcumin on inflammatory markers and lipid metabolism in streptozotocin-induced diabetic rats: a possible remedy to diabetic complications.Drug delivery and translational research · 2011Article
- Polymer particle shape independently influences binding and internalization by macrophages.Journal of controlled release : official journal of the Controlled Release Society · 2010Article
- The cytotoxic effects of lipidic formulated gold porphyrin nanoparticles for the treatment of neuroblastoma.Nanotechnology, science and applications · 2010Article
- Development of idarubicin and doxorubicin solid lipid nanoparticles to overcome Pgp-mediated multiple drug resistance in leukemia.Journal of biomedical nanotechnology · 2009Article
- Development of biodegradable nanoparticles for oral delivery of ellagic acid and evaluation of their antioxidant efficacy against cyclosporine A-induced nephrotoxicity in rats.Pharmaceutical research · 2007Article
- Preparation and characterization of novel coenzyme Q10 nanoparticles engineered from microemulsion precursors.AAPS PharmSciTech · 2003Article
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Authors and funding
4 authors.
Funding
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Abstract
The purpose of these studies was to prepare and characterize nanoparticles into which Coenzyme Q10 (CoQ10) had been incorporated (CoQ10-NPs) using a simple and potentially scalable method. CoQ10-NPs were prepared by cooling warm microemulsion precursors composed of emulsifying wax, CoQ10, Brij 78, and/or Tween 20. The nanoparticles were lyophilized, and the stability of CoQ10-NPs in both lyophilized form and aqueous suspension was monitored over 7 days. The release of CoQ10 from the nanoparticles was investigated at 37 degrees C. Finally, an in vitro study of the uptake of CoQ10-NPs by mouse macrophage, J774A.1, was completed. The incorporation efficiency of CoQ10 was approximately 74% +/- 5%. Differential Scanning Calorimetry (DSC) showed that the nanoparticle was not a physical mixture of its individual components. The size of the nanoparticles increased over time if stored in aqueous suspension. However, enhanced stability was observed when the nanoparticles were stored at 4 degrees C. Storage in lyophilized form demonstrated the highest stability. The in vitro release profile of CoQ10 from the nanoparticles showed an initial period of rapid release in the first 9 hours followed by a period of slower and extended release. The uptake of CoQ10-NPs by the J774A.1 cells was over 4-fold higher than that of the CoQ10-free nanoparticles (P < .05). In conclusion, CoQ10-NPs with potential application for oral CoQ10 delivery were engineered readily from microemulsion precursors.
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