ReviewMolecular and cellular biochemistry2003
The cell cycle of Entamoeba histolytica.
Review in Molecular and cellular biochemistry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Experimental and Computational Insights into Apc2 Independent Apc10-Apc11a Interaction and Oxidative Stress Response in the Anaphase Promoting Complex of Entamoeba histolytica.Acta parasitologica · 2026Article
- Protists as determinants of the One Health framework.The ISME journal · 2025Review
- Unraveling the interaction between a glycolytic regulator protein EhPpdk and an anaphase promoting complex protein EhApc10: yeast two hybrid screening, in vitro binding assays and molecular simulation study.The protein journal · 2024Article
- Pathogenicity and virulence ofVirulence · 2023Review
- Acute abdominal syndrome revealing an intestinal amoebiasis: Report of two cases in Tunisia.International journal of surgery case reports · 2021Article
- Rabeprazole inhibits several functions of Entamoeba histolytica related with its virulence.Parasitology research · 2020Article
- Article
- Who Needs a Contractile Actomyosin Ring? The Plethora of Alternative Ways to Divide a Protozoan Parasite.Frontiers in cellular and infection microbiology · 2019Review
- Escherichia coli mediated resistance of Entamoeba histolytica to oxidative stress is triggered by oxaloacetate.PLoS pathogens · 2018Article
- Cellular Events of Multinucleated Giant Cells Formation During the Encystation ofFrontiers in cellular and infection microbiology · 2018Article
- Hetero-oligomer of dynamin-related proteins participates in the fission of highly divergent mitochondria from Entamoeba histolytica.Scientific reports · 2017Article
- Article
- Technical advances in trigger-induced RNA interference gene silencing in the parasite Entamoeba histolytica.International journal for parasitology · 2016Article
- Recent advances inF1000Research · 2016Review
- The chastity of amoebae: re-evaluating evidence for sex in amoeboid organisms.Proceedings. Biological sciences · 2011Review
- Short hairpin RNA-mediated knockdown of protein expression in Entamoeba histolytica.BMC microbiology · 2009Article
- Entamoeba shows reversible variation in ploidy under different growth conditions and between life cycle phases.PLoS neglected tropical diseases · 2008Article
- The dynamic nature of eukaryotic genomes.Molecular biology and evolution · 2008Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Entamoeba histolytica, is a microaerophilic protist, which causes amoebic dysentery in humans. This unicellular organism proliferates in the human intestine as the motile trophozoite and survives the hostile environment outside the human host as the dormant quadri-nucleate cyst. Lack of organelles--such as mitochondria and Golgi bodies--and an unequal mode of cell division, led to the popular belief, that this organism preceded other eukaryotes during evolution. However, data from several laboratories have shown that, contrary to this belief, E. histolytica is remarkable in its divergence from other eukaryotes. This uniqueness is witnessed in many aspects of its biochemical pathways, cellular biology and genetic diversity. In this context, I have analysed the cell division cycle of this organism and compared it to that of other eukaryotes. Studies on E. histolytica, suggest that in its proliferative phase, this organism may accumulate polyploid cells. Thus 'checkpoints' regulating alternation of genome duplication and cell division appear to be absent in this unicellular protist. Sequence homologs of several cell cycle regulating proteins have been identified in amoeba, but their structural divergence suggests that they may not have equivalent function in this organism. The regulation of cell proliferation in E. histolytica, may be ideally suited to survival of a parasite in a complex host. Analysis of these molecular details may offer solutions for eradicating the pathogen by hitherto unknown methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.