ReviewMolecular and cellular biochemistry2003
Arachidonic acid and colorectal carcinogenesis.
Review in Molecular and cellular biochemistry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Peroxisome proliferator-activated receptor-gamma 34C>G polymorphism and colorectal cancer risk: a meta-analysis.World journal of gastroenterology · 2010Pooled it
- Metabolomics assisted by transcriptomics analysis to reveal metabolic characteristics and potential biomarkers of early-onset colorectal cancer.Discover oncology · 2026Article
- Metabolomic analysis reveals key changes in amino acid metabolism in colorectal cancer patients.Amino acids · 2025Article
- Arachidonic acid metabolism as a novel pathogenic factor in gastrointestinal cancers.Molecular and cellular biochemistry · 2025Review
- Anti-colorectal cancer effects of seaweed-derived bioactive compounds.Frontiers in medicine · 2022Review
- Dietary habits affect fatty acid composition of visceral adipose tissue in subjects with colorectal cancer or obesity.European journal of nutrition · 2020Article
- Tea polyphenols and their chemopreventive and therapeutic effects on colorectal cancer.World journal of gastroenterology · 2020Review
- Arachidonic acid and colorectal adenoma risk: a Mendelian randomization study.Clinical epidemiology · 2019Article
- Serum metabolite profiling of familial adenomatous polyposis using ultra performance liquid chromatography and tandem mass spectrometry.Cancer biology & therapy · 2019Article
- Arachidonic Acid Induces the Migration of MDA-MB-231 Cells by Activating Raft-associated Leukotriene B4 Receptors.Clinical cancer drugs · 2018Article
- Composition and Concentration of Serum Fatty Acids of Phospholipids Depend on Tumour Location and Disease Progression in Colorectal Patients.Journal of medical biochemistry · 2018Article
- Potential biomarkers associated with oxidative stress for risk assessment of colorectal cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2017Review
- Plasma fatty acids and risk of colon and rectal cancers in the Singapore Chinese Health Study.NPJ precision oncology · 2017Article
- Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract.Journal of immunology research · 2016Review
- Co-expression of COX-2 and 5-LO in primary glioblastoma is associated with poor prognosis.Journal of neuro-oncology · 2015Article
- Dietary strawberry seed oil affects metabolite formation in the distal intestine and ameliorates lipid metabolism in rats fed an obesogenic diet.Food & nutrition research · 2015Article
- Phospholipid remodeling and eicosanoid signaling in colon cancer cells.Indian journal of biochemistry & biophysics · 2014Review
- Cancer stem cell phenotype is supported by secretory phospholipase A2 in human lung cancer cells.The Annals of thoracic surgery · 2014Article
- Adipose tissue fatty acid composition and colon cancer: a case-control study.European journal of nutrition · 2014Article
- Evaluation of 12-lipoxygenase (12-LOX) and plasminogen activator inhibitor 1 (PAI-1) as prognostic markers in prostate cancer.BioMed research international · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Colorectal carcinoma is a leading cause of cancer related death worldwide. This deadly disease advances through a series of clinical and histopathological stages, initiated by single crypt lesions to small benign tumors and finally to malignancy. Although some progress has been made in elucidating the formation of colorectal tumors at molecular/genetic levels, the possible mechanisms of dietary lipids in inducing and promoting colorectal tumorigenesis are poorly understood. Recent epidemiological studies, however, indicate that lipid-rich diet containing omega-6 fatty acids (i.e. linoleic acid, arachidonic acid, etc.) may somehow be related with the disease process. Rapid metabolism of arachidonic acid, increased activities of phospholipases (i.e. phospholipase-A2s), and the elevated levels of cyclooxygenase (COX) and lipoxygenase (LOX) in colonic cells were reported in various stages of the malignancy, suggesting a possible link between dietary lipids and the incidence of colorectal cancer. The major focus of this review is to delineate the recent findings on enhanced arachidonic acid metabolism and its conversion into eicosanoids during the initiation and progression of colorectal carcinogenesis. In addition, the identification and participation of various phospholipases are also discussed. It is speculated that many of these phospholipases can be used as targets for developing new drugs against colorectal as well as other adenocarcinomas.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.