ReviewMolecular and cellular biochemistry2003
Antimicrotubular drugs binding to vinca domain of tubulin.
Review in Molecular and cellular biochemistry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 64 citations in OpenAlex.
- A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.Nature communications · 2018Article
- Characterization of Toxin Complex Gene Clusters and Insect Toxicity of Bacteria Representing Four Subgroups of Pseudomonas fluorescens.PloS one · 2016Article
- Novel indole-bearing combretastatin analogues as tubulin polymerization inhibitors.Organic and medicinal chemistry letters · 2013Article
- Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents.Investigational new drugs · 2012Article
- The role of Brugia malayi ATP-binding cassette (ABC) transporters in potentiating drug sensitivity.Parasitology research · 2011Article
- Drugs that target dynamic microtubules: a new molecular perspective.Medicinal research reviews · 2011Review
- Article
- Screening a panel of drugs with diverse mechanisms of action yields potential therapeutic agents against neuroblastoma.Cancer biology & therapy · 2009Article
- Water diffusion in cytoplasmic streaming in Elodea internodal cells under the effect of antimitotic agents.European biophysics journal : EBJ · 2008Article
- Intracellular proadrenomedullin-derived peptides decorate the microtubules and contribute to cytoskeleton function.Endocrinology · 2008Article
- Isolation and identification of rhizoxin analogs from Pseudomonas fluorescens Pf-5 by using a genomic mining strategy.Applied and environmental microbiology · 2008Article
- Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity.Journal of the American Chemical Society · 2008Article
- Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel.Molecular cancer therapeutics · 2006Article
- 4-Amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole (DAT1): a cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system.British journal of pharmacology · 2005Article
- Reference profiling of the genomic response induced by an antimicrotubule agent, TZT-1027 (Soblidotin), in vitro.The pharmacogenomics journalArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies on vinca domain binding drugs were done in great details by a number of workers as it is recognized as a potential target for anticancer drug development. Their structures, properties, mode of action, success and failures as potential anticancer drug have been discussed in short details in this review. Among these drugs rhizoxin and maytansine are competitive inhibitors, and bind at the vinblastine binding site of tubulin where as others are non-competitive inhibitors. Besides binding, these drugs also differ in the extent of GTP hydrolysis, GTP exchange and in the stabilization of colchicine binding site. The toxicity level of these drugs towards the host cells and the extent of efflux of drugs by the P-glycoprotein mediated pump are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.