ArticleHistochemistry and cell biology2003
Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues.
Article in Histochemistry and cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- PDE-Mediated Cyclic Nucleotide Compartmentation in Vascular Smooth Muscle Cells: From Basic to a Clinical Perspective.Journal of cardiovascular development and disease · 2021Review
- Review
- Adenosine receptors regulate gap junction coupling of the human cerebral microvascular endothelial cells hCMEC/D3 by CaThe Journal of physiology · 2017Article
- Comprehensive RNA-Seq expression analysis of sensory ganglia with a focus on ion channels and GPCRs in Trigeminal ganglia.PloS one · 2013Article
- Update on vascular endothelial Ca(2+) signalling: A tale of ion channels, pumps and transporters.World journal of biological chemistry · 2012Article
- Heterogeneity in relaxation of different sized porcine coronary arteries to nitrovasodilators: role of PKG and MYPT1.Pflugers Archiv : European journal of physiology · 2012Article
- PDE1 isozymes, key regulators of pathological vascular remodeling.Current opinion in pharmacology · 2011Review
- Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Cyclic nucleotide-gated channels contribute to thromboxane A2-induced contraction of rat small mesenteric arteries.PloS one · 2010Article
- Are pheromones detected through the main olfactory epithelium?Molecular neurobiology · 2007Review
- Pheromone detection in male mice depends on signaling through the type 3 adenylyl cyclase in the main olfactory epithelium.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Innovative techniques and applications in histochemistry and cell biology.Histochemistry and cell biology · 2003Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclic nucleotide-gated (CNG) ion channels are Ca2+-permeable nonselective cation channels that are directly gated by the binding of cAMP or cGMP. Previous studies have identified the expression of CNGA1 channels in vascular endothelial cells. The opening of CNG channels is expected to result in a rise in endothelial cytosolic Ca2+, which may trigger multiple physiological changes. In the present study, we extensively studied the expression pattern of the functional subunit of olfactory-type CNG channels (CNGA2) in vascular tissues. Northern blot analysis detected a transcript of approximately 2.6 kb in mRNA isolated from rat aorta. RT-PCR amplified a 582-bp CNGA2 fragment from RNA samples isolated from rat aorta, bovine endothelia cell CCL-209, and rat smooth muscle cell A7r5. Furthermore, in situ hybridization and immunohistochemistry revealed that CNGA2 mRNA and proteins were expressed in the endothelium and smooth muscle layers of human coronary and cerebral arteries. In conclusion, our study indicates that CNGA2 channels are widely expressed in vascular tissues across different species. These results suggest a potential ubiquitous role of CNGA2 channels in mediating Ca2+ influx in vascular cells.
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