ArticleNaunyn-Schmiedeberg's archives of pharmacology2003
Glucocorticoid inhibition of interleukin-4 (IL-4) and interleukin-13 (IL-13) induced up-regulation of arginase in rat airway fibroblasts.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Impact of systemic steroids on asthma biomarkers: A comprehensive analysis.The World Allergy Organization journal · 2026Review
- Isoprenaline-Modified Polyethyleneimine as an Efficient Gene Delivery System for Targeted Asthma Therapy and Airway Remodeling Inhibition.Biomaterials research · 2025Article
- The Role of IL-13 and IL-4 in Adipose Tissue Fibrosis.International journal of molecular sciences · 2023Article
- Arginase impedes the resolution of colitis by altering the microbiome and metabolome.The Journal of clinical investigation · 2020Article
- Association of increased risk of asthma with elevated arginase & interleukin-13 levels in serum & rs2781666 G/T genotype of arginase I.The Indian journal of medical research · 2018Article
- The Effect ofFrontiers in pharmacology · 2017Article
- Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts.Journal of biosciences · 2014Article
- Arginase in retinopathy.Progress in retinal and eye research · 2013Review
- Anti-inflammatory effect of arginase inhibitor and corticosteroid on airway allergic reactions in a Dermatophogoides farinae-induced NC/Nga mouse model.Inflammation · 2013Article
- Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma.Journal of biomedical research · 2011Article
- Characterization of proliferative effects of insulin, insulin analogues and insulin-like growth factor-1 (IGF-1) in human lung fibroblasts.Naunyn-Schmiedeberg's archives of pharmacology · 2010Article
- Species differences in expression pattern of arginase isoenzymes and differential effects of arginase inhibition on collagen synthesis in human and rat pulmonary fibroblasts.Naunyn-Schmiedeberg's archives of pharmacology · 2010Article
- Arginase: an emerging key player in the mammalian immune system.British journal of pharmacology · 2009Review
- Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives.British journal of pharmacology · 2009Review
- Article
- Arginase and pulmonary diseases.Naunyn-Schmiedeberg's archives of pharmacology · 2008Review
- Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma.Current molecular medicine · 2008Review
- Arginases I and II in lungs of ovalbumin-sensitized mice exposed to ovalbumin: sources and consequences.Toxicology and applied pharmacology · 2008Article
- Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma.Respiratory research · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arginase appears to play a significant role in the pathogenesis of inflammatory and obstructive airway diseases by interfering with NO synthesis (hyperreactivity) and by providing substrate for collagen synthesis (remodelling). IL-4 and IL-13 are key proinflammatory cytokines in asthma, and their effects on arginase in rat primary airway fibroblasts in culture were studied. Airway fibroblasts showed significant arginase activity, which was higher when the culture medium contained 10% fetal calf serum (FCS) (20 mU/mg protein) compared to 5% FCS (6 mU/mg protein). In presence of 10% FCS addition of IL-4 or IL-13 (10 ng/ml each) for 20 h or 40 h caused an increase in arginase activity by 76% and 160% (IL-4) and by 134% and 213% (IL-13), respectively. Using RT-PCR mRNA for arginase I was clearly detectable with 30 PCR cycles, whereas mRNA for arginase II was hardly detectable with 35 PCR cycles. IL-4 and IL-13 caused a clear increase in the mRNA of both arginase isoenzymes. Dexamethasone (1 microM) did not affect basal arginase activity, but largely opposed the stimulatory effects of IL-4 and IL-13. In conclusion, IL-4 and IL-13 can cause a marked up-regulation of arginase activity in rat airway fibroblasts and these effects can be inhibited by glucocorticoids.
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